Senior Scientist or Scientist - Drug Metabolism and Pharmacokinetics (DMPK)

St. Jude Children's Research Hospital•Memphis, TN

2d•$104,000 - $186,160•Onsite

About The Position

We are seeking a highly motivated, hands-on scientist to join our academically-oriented team supporting primarily small-molecule drug discovery and development. This laboratory-based role requires direct execution of bioanalytical, in vitro DMPK, and in vivo PK studies. The successful candidate will have a track record of executing such work directly rather than managing or outsourcing it. This is a bench-focused position emphasizing practical, experimental work across a DMPK-style workflow in an academic, non-profit environment.

Requirements

Demonstrated experience with LC-MS/MS bioanalysis for small molecules.
Practical laboratory experience running in vitro DMPK/ADME assays (protein binding, microsomes, hepatocytes, monolayers).
Direct hands-on experience executing in vivo PK studies (dosing, sampling, tissue collection).
Working knowledge of preclinical formulation techniques (solutions and suspensions).
Strong attention to detail, organizational skills, and ability to plan and work independently while collaborating effectively.
Bachelor's degree in Chemistry, Biology, Pharmacology, Pharmaceutical Sciences, or related discipline is required.
Scientist Minimum Experience: Eight (8) years of relevant work experience is required.
Six (6) years of relevant work experience is required with a Master's degree.
Three (3) years of relevant work experience is required with a PhD.
Senior Scientist Minimum Experience: Ten (10) years relevant work experience is required.
Eight (8) years of relevant work experience is required with a Master's degree.
Five (5) years of relevant work experience is required with a PhD.

Nice To Haves

Experience with SCIEX instrumentation preferred.
Non-regulated/discovery BA setting is acceptable.

Responsibilities

Perform quantitative LC-MS/MS bioanalysis of small and/or large molecules in biological matrices (plasma, tissues, etc.) from in vitro and in vivo studies to support PK/PD, ADME, and efficacy evaluations.
Execute in vitro DMPK assays, including plasma protein binding, microsomal stability incubations, hepatocyte metabolism studies, and permeability assessments in cell monolayers.
Conduct in vivo PK studies, dosing by various standard routes, terminal and non-terminal blood sampling, and organ/tissue collection.
Develop and/or prepare preclinical formulations by dissolving or suspending test agents for in vivo dosing.
Analyze data, maintain accurate records (LIMS, lab notebooks, reports), and communicate results to the Director and project team in a fast-paced environment.
Performs other related duties as assigned in order to meet the goals of the department and institution.
Maintains regular and predictable attendance.