Senior Research Scientist – Pharmacokinetics

AbCellera•Vancouver, BC

9h•CA$112,000 - CA$132,000•Onsite

About The Position

Each of us cares about someone who will need medicines. That’s why our vision is to repeatedly beat the odds to deliver breakthrough medicines to patients that need them. We pursue truth and scientific rigour and have the courage to work at the edge of the unknown. We are seeking a highly motivated Senior Research Scientist with a strong understanding of pharmacokinetics and bioanalytical methods to join our multidisciplinary Pharmacokinetics (PK) team. Based in Vancouver, you will be instrumental in bridging the gap between discovery and the clinic, specifically driving the bioanalytical and ADME strategies and execution with a focus on antibody drug conjugate (ADC) programs. In this role, you will collaborate with cross-functional teams, including non-clinical safety, modeling and simulations, protein sciences, and the clinical and regulatory teams, to support the progression of our projects from discovery to development.

Requirements

Expert in the design, development, and phase-appropriate qualification/validation of LC/MS-MS bioanalytical assays to support preclinical and clinical development
Demonstrated expertise in authoring sections of regulatory submissions
Comfortable with non-compartmental data analysis (WinNonlin), and have a good understanding of PK parameters
8+ years of relevant industry experience in addition to a PhD in Biology, Pharmacology, or related discipline; candidates with a MSc and 10+ years of industry experience will also be considered
Genuinely curious and energized by working with teammates to discuss innovative ideas in a highly collaborative and fast paced environment
Excel in documentation and organizational skills and clearly communicate scientific and technical concepts both verbally and in writing

Nice To Haves

Direct experience with PK profiling of ADCs (considered a strong asset)

Responsibilities

Leading external activities for establishing, qualifying, and validating ligand-binding assays and LC-MS/MS methods to support the preclinical and clinical development of novel ADC therapeutics, including measurement of drug concentration and anti-drug antibodies
Characterizing the ADME profile for ADC candidates, including assessing the drug-drug interaction (DDI) potential of released small molecule payloads
Leading the analysis, interpretation, and reporting of PK/ADME data to support regulatory filings (IND/CTA), including authoring and reviewing high-quality study reports, briefing packages, and regulatory documents
Collaborating with cross-functional project teams where you'll represent the PK function, and interacting externally with CROs or consultants
Training and mentoring scientists