Senior Pharmacometrician

Entrada Therapeutics•Boston, MA

15h•Remote

About The Position

Entrada Therapeutics is seeking a dynamic and motivated Senior Pharmacometrician with deep quantitative pharmacology expertise. This role reports to the Head of Clinical Pharmacology and partners across functions within a growing organization. The ideal candidate will have a strong background in the applications of model-based drug development within the biotechnology or pharmaceutical industry. The ideal candidate is passionate about translating science into approved and accessible medicines.

Requirements

Ph.D. in pharmaceutical sciences, pharmacology, pharmacometrics, pharmacokinetics, or related discipline or Pharm.D. or M.D. with relevant experience.
3+ years’ experience with a background in the application of mathematical, pharmacokinetics, and statistical methods within pharma/biotech industries or drug development.
Experience using Phoenix WinNonlin, R, NONMEM, MATLAB, or other pharmacokinetic and modeling software.
Strong mathematical model development and analytical skills.
Proficient documentation and organizational skills, as well as proven ability to be self-motivated and able to work independently.
Excellent communication and presentation skills to efficiently relay information to project teams and other key stakeholders.

Responsibilities

Use modeling approaches to advance clinical and translational research at Entrada Therapeutics.
Lead cross-functional teams with scientific acumen to develop and execute pharmacometrics for programs across all phases of drug development.
Support the development of diverse modeling strategies and execution, in collaboration with the Head of Clinical Pharmacology, to bring value to the Entrada portfolio.
Work collaboratively with functional partners, including Clinical Development, Biostatistics, Non-Clinical Product Development, Clinical Operations, and Regulatory to deliver on both project team and corporate objectives.
Author regulatory documents including analysis plans, study reports, population PK reports, exposure-response analyses reports and other similar documents.
Execute pharmacometrics analyses independently to support internal and external decision making and address key drug development questions.
Integrate pharmacometrics insights into core deliverables supporting drug development milestones and governance or decision boards.
Monitor work with CROs and other external vendors to ensure compliance with agreed protocols, quality standards, and timelines.