Senior Manager, Program Management

Mirum Pharmaceuticals•Foster City, CA
•$180,000 - $200,000•Hybrid

About The Position

Mirum Pharmaceuticals is a biopharmaceutical company focused on transforming the treatment of rare diseases. The Senior Program Manager, Drug Development partners with the Program Lead and cross-functional Development Team to shape and execute integrated program strategy and long-range plans from preclinical development through regulatory approval and commercialization. The role drives alignment and disciplined execution across scope, schedule, risks and issues, budget, resources, governance, and stakeholder communications, connecting research, CMC, nonclinical, clinical, regulatory, and commercial functions to support clear goals, informed decisions, and coordinated delivery of program milestones. The position also supports effective cross-functional governance, anticipates key development decisions, and contributes to the evolution of Program Management tools, processes, standards, and ways of working. It may include coaching, mentoring, or oversight of other Program Management staff.

Requirements

  • BA/BS in a life sciences discipline with at least 5 years of multidisciplinary pharmaceutical or biotechnology industry experience in program management, or a master's or PhD degree with at least 4 years of relevant experience.
  • Experience supporting drug development programs through key clinical and/or regulatory milestones, demonstrating knowledge of the drug development process.
  • Demonstrated understanding of program and project management practices, tools, and methodologies, including integrated planning, critical path analysis, risk management, scenario planning, and status reporting.
  • Ability to facilitate cross-functional teams, manage conflict, build consensus, and promote timely, high-quality decision-making without direct authority.
  • Excellent communication, facilitation, problem-solving, analytical thinking, stakeholder management, and organizational skills.
  • Ability to independently manage multiple priorities, objectives, timelines, and deadlines across programs or workstreams.
  • Collaborative team member who creates clarity, accountability, and alignment across diverse functional perspectives.
  • Ability to connect program-level decisions to portfolio and company priorities.
  • Pragmatic problem solver who anticipates challenges, frames options, and drives action.
  • Credible partner who communicates transparently and adapts effectively to different audiences, including senior leaders.
  • Continuous-improvement mindset and willingness to introduce and scale effective tools and practices.

Nice To Haves

  • Proficiency with planning tools such as Microsoft Project or comparable project management software.
  • Experience using or implementing AI tools.
  • PMP certification.

Responsibilities

  • Partner with the Program Lead and Development Team to develop, maintain, and execute cross-functional program strategy and integrated development plans.
  • Establish and maintain integrated program schedules to analyze critical path activities, dependencies, milestones, and resource constraints.
  • Identify, assess, and track program risks and issues; facilitate mitigation and contingency planning and escalate material concerns through governance channels.
  • Support scenario planning around milestones and decision points, evaluating trade-offs, alternative outcomes, and opportunities to accelerate development.
  • Connect short-, mid-, and long-term functional plans and highlight interdependencies, assumptions, and potential impacts on program objectives.
  • Partner with the Program Lead to facilitate cross-functional team and governance meetings, including agenda development, decision framing, outcome documentation, and action follow-through.
  • Provide timely and transparent program reporting to stakeholders and leadership on milestones, key decisions, risks, resource needs, and team accomplishments.
  • Build relationships with functional partners and leaders across research, CMC, nonclinical, clinical development and operations, regulatory, and commercial teams.
  • Serve as a Program Management subject matter resource and contribute to the evolution of Program Management tools, processes, standards, and ways of working.
  • Contribute to Program Management department goals and initiatives and potentially coach, mentor, or oversee other Program Management staff.
  • Perform other duties as assigned.
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