Senior Manager, AI Portfolio & Prioritization Lead

Pfizer • New York City, NY

18h

About The Position

The AI Portfolio & Prioritization Lead reports directly to the AI Strategy & Realization Lead within PGS Data, Analytics & AI Transformation. The role owns PMO management across the AI Strategy & Realization team, providing portfolio discipline to ensure work is prioritized, resourced, and delivered against strategic value. It oversees intake and prioritization of projects and programs across all team pillars, sequencing work according to strategic alignment, value, and capacity.

The role manages financial tracking for the full portfolio and partners with the PGS Data, Analytics & AI Transformation portfolio team and the Spark team to align intake, value realization, and inventory standards. It tracks value realization and holds pillar teams accountable for defining, measuring, and reporting benefits. It also partners with the PGS and Digital Responsible AI team to support compliance with governance standards, including AIRIF, DPAL, and ITRM. The role maintains a current initiative inventory and provides leadership-ready reporting on portfolio status, risk, and resourcing, helping teams focus on high-value work and demonstrate outcomes.

Requirements

• Bachelor’s degree in Business, Information Systems, Computer Science, or a related field and at least 6 years of experience; or a master’s degree and at least 5 years of experience; or a PhD and at least 1 year of experience.
• Demonstrated experience running a PMO, portfolio management function, or project intake process within a large, matrixed organization.
• Working knowledge of prioritization and value realization frameworks, with the ability to translate strategic priorities into a sequenced, resourced portfolio.
• Experience with financial tracking and reporting for a multi-project or multi-program portfolio.
• Ability to partner effectively with adjacent portfolio, governance, and compliance teams to align standards and ways of working across organizations.
• Familiarity with AI/analytics governance and compliance concepts and ability to work with frameworks such as AIRIF, DPAL, and ITRM.
• Excellent organizational, analytical, and communication skills, including the ability to hold stakeholders accountable without direct authority.
• Ability to travel domestically and internationally up to 10% of the year.
• Willingness to work off-hours to accommodate global time zones and support teams and stakeholders across sites.
• Willingness to work extended or non-standard hours during peak periods, including portfolio planning cycles, financial reporting deadlines, and value realization reviews.
• Must be authorized to work in the United States by any employer; U.S. work visa sponsorship is not available.
• Requires permanent work authorization in the United States.

Nice To Haves

• Strong Pfizer colleague network, particularly across PGS, Digital, and Data, Analytics & AI Transformation, with a track record of building partnerships in complex areas.
• Experience with Pfizer's portfolio, intake, and value realization standards, including familiarity with the Spark team's ways of working.
• Familiarity with Pfizer's responsible AI and technology risk/compliance frameworks, including AIRIF, DPAL, and ITRM.
• Experience in pharmaceutical manufacturing or supply chain operations.
• Proven program or portfolio management capability, including successful execution of initiatives across large, globally distributed teams.

Responsibilities

• Own PMO management and portfolio sequencing across the AI Strategy & Realization team, reporting on portfolio health and priorities to the AI Strategy & Realization Lead.
• Lead project and program intake and prioritization based on strategic initiatives and value, establishing a consistent and transparent process for evaluating and sequencing new and in-flight work.
• Partner with the PGS Data, Analytics & AI Transformation portfolio team and the Spark team to align intake, value realization, and inventory standards across PGS.
• Manage financial tracking for projects across all AI Strategy & Realization pillars and maintain an accurate, current view of investment and spend.
• Capture and track value realization, and hold pillar teams accountable for consistent definition, measurement, and reporting of benefits.
• Partner with the PGS and Digital Responsible AI team to ensure portfolio adherence to compliance and governance standards, including AIRIF, DPAL, and ITRM.
• Maintain a current inventory of AI Strategy & Realization initiatives and provide leadership-ready reporting on status, risk, and resourcing across pillars.
• Identify portfolio capacity constraints and competing priorities, and escalate trade-off decisions to the AI Strategy & Realization Lead and pillar leaders as needed.

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution.
• Paid vacation, holiday, and personal days.
• Paid caregiver/parental and medical leave.
• Medical, prescription drug, dental, and vision coverage.
• Eligible to participate in Pfizer’s Global Performance Plan, with a bonus target of 17.5% of base salary.
• Eligible to participate in a share-based long-term incentive program.
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior