Senior IT Systems Engineer

10x Genomics•Pleasanton, CA

About The Position

10x Genomics is seeking a Senior Systems Engineer to join its IT team. The role supports the company’s global mission-critical IT infrastructure for research and development, manufacturing, and business operations. The engineer will build and operate secure, stable, scalable Windows enterprise systems and services, with a focus on virtualization, identity services, and production infrastructure. The position requires collaboration with a diverse team and participation in operational support and incident prevention.

Requirements

At least 5 years of IT experience managing Windows infrastructure and core services, including Active Directory, Microsoft Entra ID, endpoint management, DNS, and DHCP, in a production environment.
Extensive experience with virtualization technologies and hypervisors such as VMware ESXi/vCenter and Proxmox VE.
Experience with system architecture and building production environments on AWS.
Experience with enterprise backup, disaster recovery, alerting, and monitoring solutions.
Strong understanding of encryption, data security, and patch management best practices.
Experience scripting in PowerShell, Bash, or Python.
Experience with infrastructure-as-code and configuration management tools such as Ansible and Terraform to automate system provisioning.

Nice To Haves

Working knowledge of Linux system administration, including building systems, management, permissions, and network mounts.
Familiarity with identity and access management tools and SAML 2.0/OIDC protocols.
Familiarity with Microsoft Intune for unified endpoint management and policy enforcement.
Strong analytical and organizational skills.
Excellent oral and written communication skills.

Responsibilities

Design, build, maintain, and monitor mission-critical Windows enterprise infrastructure systems and services across the global footprint.
Manage the Global Active Directory and Microsoft Entra ID environment.
Maintain a secure and stable IT environment through patch management, policy enforcement, systems hardening, and system and software upgrades.
Manage enterprise backup and disaster recovery solutions.
Create and maintain detailed documentation of system design, implementation, and configuration.
Participate in a shared operational on-call rotation to support the production environment.
Lead post-incident reviews, identify root causes, and implement long-term preventative fixes.