Senior Global Medical Affairs Lead CVRM

AstraZeneca • Cambridge, MA

7d • $243,569 - $365,379 • Hybrid

About The Position

The Senior Global Medical Affairs Lead for Cardiovascular, Renal and Metabolism (CVRM) is a highly experienced Medical Affairs leader who develops and leads global medical strategies and practice-change initiatives. Reporting to the Medical Head, this role guides cross-functional and cross-regional teams and shapes global medical agendas through Global Medical Team, Global Product Team, and Disease Area Team leadership, partnering closely with Medical and Commercial functions across markets and regions.

The role drives innovative approaches to market and healthcare-system change, evidence generation, stakeholder engagement, and medical initiatives. It applies an understanding of healthcare pathways, regulatory landscapes, market access, and competitive dynamics, and uses digital capabilities and advanced analytics to identify opportunities in preparation for launches and throughout product life cycles.

The Senior GMAL owns evidence-generation strategy, including clinical research, Phase 2–4 interventional trials, registries, and real-world evidence programs. The role guides the optimisation, communication, and strategic rollout of evidence across scientific platforms, supporting regulatory, payer, and healthcare-provider needs. It also uses digital health tools, data platforms, and analytics to improve evidence communication, stakeholder engagement, and patient outcomes, while ensuring scientific communications are accurate and compliant.

The position builds relationships across the healthcare ecosystem, including global and regional KOLs, professional societies, regulators, payers, patient organisations, digital innovators, and health systems. It mentors and guides cross-functional teams, anticipates regulatory and payer evidence requirements, and ensures evidence-generation initiatives are designed for scientific and regulatory success. The role is based in Gaithersburg, Maryland, or Boston, Massachusetts, and requires office attendance three days per week.

Requirements

• Master’s degree or higher.
• At least 5 years of experience in the pharmaceutical industry in Medical, Marketing, R&D, or Market Access, or extensive experience within a health system, such as clinical practice, pharmacy, or pathway design.
• Demonstrated leadership in complex global healthcare environments, including franchise or therapeutic-area leadership in key markets, brand performance, management of large diverse teams, and global launches of major products.
• Significant expertise in healthcare-system pathways, regulatory landscapes, market shaping, and external stakeholder engagement.
• Strong track record of building internal and external networks and collaborating across geographies and matrix teams.
• Experience mentoring junior colleagues or peers.
• Digital proficiency, including use of digital health tools and data platforms to advance evidence generation and communication.
• Deep understanding of patient-care pathways, evolving treatment protocols, scientific literature, and contemporary healthcare transformation.
• Ability to guide, influence, and align diverse stakeholders, including thought leaders, regulatory bodies, patient groups, and payer organisations.

Nice To Haves

• Doctoral-level degree (MD, PhD, or PharmD) in a relevant discipline.
• Recognized expertise in the relevant or a related therapeutic area, demonstrated through clinical practice, research leadership, or significant external engagement.
• Advanced experience designing, leading, and interpreting clinical research programs, including pivotal Phase 2–4 trials, practice-changing real-world evidence studies, and innovative evidence-generation approaches.
• Experience beyond Medical Affairs, such as prior roles in Marketing, R&D, or Market Access.
• Long-standing relationships with global KOLs, societies, regulators, digital health partners, and innovative healthcare organisations.
• Track record of launching products or indications in multiple diverse markets, such as the US, China, and EU, and developing and executing global medical strategies.

Responsibilities

• Develop and lead global product and disease-area medical strategies and practice-change initiatives.
• Lead cross-functional and cross-regional teams and shape global medical agendas through Global Medical Team, Global Product Team, and Disease Area Team leadership.
• Drive innovative, data-informed approaches to market shaping, launch preparation, and life-cycle management.
• Own evidence-generation strategy, including clinical research, Phase 2–4 trials, registries, and real-world evidence programs.
• Guide the optimisation, communication, and strategic rollout of evidence to meet regulatory, payer, and healthcare-provider needs.
• Use digital health tools, advanced analytics, and data platforms to transform evidence communication and stakeholder engagement.
• Develop compelling scientific narratives and ensure accurate, impactful, compliant scientific communications.
• Build and sustain relationships with KOLs, professional societies, regulators, payers, patient organisations, digital innovators, and health systems.
• Mentor and guide cross-functional teams and promote scientific leadership and strategic collaboration.
• Anticipate regulatory and payer evidence requirements and ensure high-quality, compliant evidence generation and communication.
• Lead franchise or therapeutic-area business in key markets, drive brand performance, manage large diverse teams, and support global product launches.

Benefits

• Short-term incentive bonus opportunity.
• Eligibility to participate in an equity-based long-term incentive program for salaried roles.
• Retirement contribution for hourly roles.
• Commission payment eligibility for sales roles.
• Qualified retirement program (401(k) plan).
• Paid vacation and holidays.
• Paid leaves.
• Medical, prescription drug, dental, and vision coverage.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior