Senior Endpoint Systems Engineer (HYBRID: Chicago)

Tempus AI•Chicago, IL

34d•$130,000 - $145,000•Hybrid

About The Position

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. Location: Hybrid: Chicago (3 days on-site) Position Overview: We are seeking a highly skilled and strategic Senior Endpoint Systems Engineer to join our IT team. In this role, you will serve as the primary architect and technical lead for the health, security, compliance, and lifecycle management of our global endpoint fleet. Our environment features a balanced mix of both Windows and macOS devices. We need a senior professional with deep, dual-platform expertise who can design scalable deployment workflows, architect robust endpoint security configurations, and optimize our enterprise toolset—specifically Microsoft Intune, Jamf Pro, and Workspace ONE. As a senior member of the team, you will drive technical strategy, lead complex integration projects, and mentor junior IT staff to ensure a seamless and secure digital employee experience.

Requirements

5–8+ years of dedicated experience in endpoint engineering, systems administration, or infrastructure architecture within an enterprise environment.
Comprehensive, expert-level knowledge of both Windows and macOS operating systems, system internals, and enterprise deployment methodologies.
Deep hands-on engineering experience configuring and managing Microsoft Intune, Jamf Pro, and Workspace ONE at scale.
Strong proficiency in PowerShell and Bash/Zsh (Python or Swift is a significant plus) for advanced automation, custom scripts, and utilizing MDM APIs.
Proven ability to lead projects independently, collaborate across multi-functional engineering teams, and explain complex technical concepts to non-technical stakeholders.

Nice To Haves

Python or Swift is a significant plus

Responsibilities

Architect, optimize, and maintain our global Unified Endpoint Management (UEM) infrastructure using Microsoft Intune, Jamf Pro, and VMware Workspace ONE.
Design and scale automated deployment, provisioning, and configuration management workflows for a balanced fleet of Windows 10/11 and macOS hardware.
Standardize and evolve modern deployment frameworks utilizing Windows Autopilot, Apple Business Manager (ABM), and Automated Device Enrollment to achieve zero-touch provisioning.
Develop, test, and maintain robust code repositories (PowerShell for Windows; Bash/Zsh/Python for macOS) to automate complex administrative tasks, custom reporting, and API integrations.
Partner closely with the Security team to engineer and enforce endpoint security baselines (e.g., CIS Benchmarks), disk encryption protocols (BitLocker, FileVault), and EDR/antivirus agent deployments.
Lead the integration of endpoint platforms with enterprise identity and access management (IAM) systems (e.g., Entra ID, Okta), including modern single sign-on (SSO) extensions.
Act as the highest tier of technical escalation for complex endpoint, OS, and software issues.
Provide mentorship, guidance, and technical training to Tier 1/2 service desk and junior systems administrators.
Maintain a forward-looking roadmap for endpoint technologies, evaluate emerging tools, and author authoritative architectural diagrams and standard operating procedures (SOPs).