Senior Director, Solid Tumor Asset Lead, Translational Development

Bristol Myers Squibb • Madison, NJ

20h • Hybrid

About The Position

Bristol Myers Squibb has pioneered the development of immuno-oncology therapies and continues to diversify in drug development for the treatment of cancers. Our world-class Translational Development organization is exploring new aspects of tumor and immune biology to create tailored, individualized treatment strategies that will offer the greatest possible benefit to patients. We are looking for experienced translational scientists to help drive improved understanding of disease biology, mechanism of action, and predictive biomarkers in our late-stage clinical oncology portfolio. Ideal candidates will possess a strong scientific background, effective communication skills, and experience working in a matrixed industrial environment.

The Asset Lead role will be responsible for development and execution of translational strategies in solid tumor oncology for assigned programs. Key responsibilities of this role are to act as a lead scientist to implement and generate and deliver on innovative biomarker strategies for clinical programs including patient selection, differentiation, resistance, combinations and indication selection. The Asset Lead will develop reports and publications on translational data generated to support asset development and contribute to regulatory submissions. This individual will work on cross-functional project teams to drive execution of translational/biomarker plans working with disease and lab scientists, as well as BMS members from clinical, medical, commercial, regulatory, and diagnostics. Individual will also engage with external academic collaborators/Key Opinion Leaders (KOLs).

Requirements

• Ph.D. in Oncology/Hematology or related field with 12+ years of industry experience including significant time in translational capacity
• Requires comprehensive knowledge of principles, concepts and / or methodologies within drug discovery or clinical development
• Has significant understanding of the role of translational research/medicine and clinical biomarkers in drug development
• Demonstrated knowledge of oncology and/or tumor-immunology disease biology
• In-depth understanding of solid tumor oncology with knowledge of current and evolving clinical landscape and competitive scenarios, with therapeutic area experience a plus
• Strong scientific background with demonstrated impact using clinical, translational, and mechanistic data
• In depth understanding of early or late-stage drug and translational development process with proven track record of successful implementation of biomarker strategy
• Clinical protocol authoring and review of regulatory documents
• Working knowledge of technological platforms covering biomarker measures including but not limited to genomics, gene expression, immune profiling, and flow cytometry.
• Excellent data analysis and problem-solving skills
• Exceptional verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications/reviews, scientific presentations and regulatory submissions (INDs/NDAs) with ability to synthesize complex scientific concepts into simple communication points
• Proven track record of writing and publishing scientific articles as major scientific contributor
• Proven scientific/project leadership expertise and experience working on complex global teams, managing people/projects as well as leading external collaborations
• Experience interacting with health authorities

Nice To Haves

• Preferably has strong understanding of modality agnostic therapies including small molecules and biologics

Responsibilities

• Integrate translational research and clinical development, developing biomarker strategies in alignment with clinical development objectives, leading efforts for data generation and interpretation and for communication to the development teams.
• Responsible for understanding external research environment, partnering with other functions both internally and externally to coordinate the execution of Translational development deliverables.
• Engages functional groups to develop, champion, implement and align biomarker strategies for development projects in support of the overall R&D portfolio goals.
• Effectively engages with teams and matrix leadership to define, revise and progress translational biomarker plans.
• Continually analyzes progress, engages in critical thinking, and asserts strong problem-solving towards delivering key data and interpretations essential for decision making.
• Delivers high quality biomarker strategies for understanding mechanism of action/resistance, target engagement, pharmacodynamics endpoints and patient selection.
• Ensures the output of the biomarker plans meets established project standards.
• Engages team members to ensure alignment of biomarker strategies with clinical operational plans and with functional area capabilities to execute and deliver on robust translational biomarker data package to support trial and program
• Builds productive relationships with team members that interact with the translational clinical biomarker group.
• Effectively interfaces with functional areas to ensure strategic alignment and to identify resources needed to deliver on biomarker goals.
• Communicates key biomarker program information, risks, and milestones, and manages information flow across team members

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree