Senior Director, Product Strategy

Kardigan•Princeton, NJ

8h•Hybrid

About The Position

Kardigan is a heart health company focused on making cardiovascular disease preventable and curable. The company aims to develop targeted treatments for cardiovascular diseases. Led by experienced co-founders who previously led MyoKardia, Kardigan possesses a cutting-edge discovery platform, a pipeline of late-stage candidates, and a driven team dedicated to improving patient lives. The company's values—patient-driven, authentic, eager to learn, committed to winning as a team, and enabling the impossible—guide their work and foster innovation. The Product Strategy team operates at the intersection of science, clinical development, commercial, and corporate strategy. They translate Kardigan's pipeline into clear product visions, target product profiles, value propositions, and lifecycle strategies, ensuring all development decisions are data-driven and focused on long-term portfolio value. The team collaborates closely with various departments to provide strategic framing and analytics for portfolio governance and investment decisions. They play a crucial role in shaping programs, building capabilities in competitive intelligence and market access, and ensuring product strategies prioritize patients. All Kardigan product candidates are investigational, and references to launch and commercialization pertain to readiness planning for potential future approvals.

Requirements

Bachelor’s degree from an accredited four-year college or university in a scientific, health, or business discipline.
8+ years of experience in biotech, pharmaceutical, or life sciences strategy consulting, including direct experience supporting product, portfolio, or asset strategy for late stage clinical programs.
Demonstrated experience developing core product strategy deliverables — target product profiles, value propositions, competitive assessments, or market landscape analyses — for one or more clinical-stage assets.
Proven experience working cross-functionally with R&D, Commercial, Regulatory, and Market Access colleagues and leading workstreams through influence without direct authority.
Strong analytical capability, including hands-on experience with financial modeling, forecasting, and program valuation.
Strong scientific literacy and working knowledge of clinical development, regulatory pathways, and competitive dynamics.
Excellent written and verbal communication skills, including preparation of clear executive-level presentations.
Ability to work on-site four days per week in Princeton, New Jersey with flexibility to travel approximately 10–15% across Kardigan’s South San Francisco, Princeton, and Chicago sites.

Nice To Haves

Advanced degree (PhD, MD, PharmD, or MBA).
Experience in cardiovascular preferred.
Exposure to pre-launch or launch planning, including pricing and reimbursement or evidence-generation strategy development.
Experience presenting to senior governance and influencing executive audiences.
Experience mentoring junior team members and coordinating the work of analysts, consultants or matrixed contributors.
Experience in a fast-paced, entrepreneurial biotech environment, with a strong patient-centric orientation and continuous-improvement mindset.

Responsibilities

Develop, maintain, and evolve the integrated product strategy for the assigned program, ensuring it reflects current clinical data, competitive dynamics, and portfolio priorities.
Draft and iterate the target product profile (TPP), value proposition, and differentiation strategy for the assigned program, and drive cross-functional input and alignment on the evidence required to support them.
Partner with Clinical Development and Medical Affairs on the assigned program to provide product strategy input into trial design, endpoint selection, and evidence-generation planning.
Conduct scenario planning and trade-off analyses across indications, lines of therapy, and geographies for the assigned program, and frame options and implications for review by product strategy leadership and the Global Program Head.
Maintain our evolving perspective on the competitive environment and generate insights leveraging continuous data generation and identifying issues to monitor.
Generate insights based on competitive intelligence.
Build and maintain the program-level commercial fact base — market landscape, patient flow, unmet need, and competitive positioning — that supports portfolio decision-making and governance reviews.
Own key forecast assumptions which will enable financial models, forecasting inputs, and program valuation analyses in partnership with the forecasting Center of Excellence to support stage-gate decisions, new indication assessments, and development plan modifications.
Prepare clear, decision-ready materials and recommendations for portfolio governance forums, for review and sponsorship by product strategy leadership.
Track key performance indicators and impact measures for the assigned program’s integrated product strategy and report progress, risks, and mitigation options.
Support business development evaluations related to the assigned program or disease area, contributing market, competitive, and strategic analyses to due diligence efforts.
Provide commercial perspectives that inform our individual new program decisions such as lifecycle management programs.
Partner with the commercial organization to develop and refine launch plan.
Drive assigned workstreams within the cross-functional launch-readiness plan for the program, in anticipation of potential future approvals, coordinating deliverables and timelines across contributing functions.
Work with Regulatory and Market Access to document regulatory pathway, pricing, and reimbursement considerations for the assigned program, drawing on the market access Center of Excellence.
Own evolving go-to-market strategy globally; identifying new markets, sequencing entry and defining go-to-market model.
Serve as the day-to-day product strategy partner to the Global Program Head and cross-functional Global Program team, leading through influence to drive alignment without direct authority.
Facilitate resolution of cross-functional questions on program strategy, escalating conflicts and portfolio-level implications to product strategy leadership with clear options.
Contribute to the Product Strategy function’s frameworks, templates, and ways of working, and may provide day-to-day guidance to analysts or Center of Excellence staff supporting the program.