Global Commercial Strategy (GCS) Oncology: Senior Director, Portfolio Strategy

Pfizer • New York City, NY

2d • Hybrid

About The Position

The Senior Director, Oncology Portfolio Strategy is a senior strategic leader responsible for shaping Pfizer’s long-term Oncology portfolio strategy and investment agenda. The role develops commercial portfolio strategies across tumor types, modalities, and innovation platforms to support disciplined investment decisions that maximize patient impact and portfolio value.

The position advises Oncology leadership by translating scientific, clinical, commercial, competitive, and financial insights into enterprise-level recommendations. It works across Research, Development, Commercial, Medical, Access, Business Development, Finance, Regulatory, and other functions to lead portfolio prioritization, resource allocation, external innovation assessments, and long-range strategic planning. The Senior Director also advances portfolio management frameworks, governance processes, and decision-support capabilities, including AI-enabled ways of working.

This role provides senior leadership to matrixed teams and strategic initiatives, supports governance and portfolio reviews, and mentors colleagues. The position is hybrid. Relocation assistance may be available based on business needs and/or eligibility. Candidates must have permanent U.S. work authorization; U.S. work visa sponsorship is not available.

Requirements

• Bachelor’s degree required.
• 12 or more years of successful, progressive experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, business development, strategy consulting, corporate strategy, or a related field.
• Experience in Oncology.
• Demonstrated experience leading enterprise-level strategic initiatives and influencing significant investment decisions.
• Experience leading highly visible cross-functional initiatives in complex matrix organizations.
• Ability to synthesize scientific, clinical, commercial, competitive, and financial information to support portfolio prioritization and capital allocation decisions.
• Strong strategic, analytical, and financial acumen, including experience evaluating risk, uncertainty, and value creation across multiple opportunities.
• Track record of influencing senior leadership and driving alignment among diverse stakeholder groups.
• Excellent communication, facilitation, organizational, and executive-ready storytelling skills.
• Breadth of diverse leadership experience and capabilities, including influencing and collaborating with peers, developing and coaching others, and guiding colleagues’ work to achieve meaningful outcomes and business impact.
• Ability to thrive in ambiguity, make recommendations with incomplete information, and lead teams through evolving portfolio priorities.
• Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters.
• Permanent work authorization in the United States; U.S. work visa sponsorship is not available.

Nice To Haves

• Advanced degree in business, life sciences, medicine, pharmacy, public health, or a related field.
• Experience developing long-range portfolio strategies across multiple disease areas, modalities, or therapeutic platforms.
• Experience supporting governance bodies, investment committees, or enterprise portfolio reviews.
• Demonstrated success shaping portfolio prioritization frameworks, resource allocation decisions, and strategic trade-off discussions.
• Experience assessing internal pipeline and external innovation opportunities, including licensing, partnerships, and acquisitions.
• Deep understanding of portfolio management principles, valuation methodologies, forecasting, and investment decision-making.
• Deep understanding of the oncology ecosystem, including standards of care, emerging science, competitive dynamics, and future market evolution.
• Experience evaluating opportunities across multiple tumor types and mechanisms rather than a single disease area.
• Ability to connect scientific innovation with portfolio-level value creation and strategic differentiation.
• Experience advising senior executives on complex strategic decisions with significant business impact.
• Demonstrated ability to lead through ambiguity and navigate competing stakeholder priorities.
• Experience establishing strategic frameworks, processes, or capabilities that improve organizational decision-making.
• Comfort operating in an AI-enabled or AI-augmented environment; experience using AI tools for strategy, synthesis, scenario planning, or analysis is a plus.

Responsibilities

• Lead development and evolution of the Oncology portfolio strategy, identifying high-value opportunities across tumor types, mechanisms, modalities, and therapeutic platforms.
• Develop long-range portfolio scenarios and strategic roadmaps to inform investment priorities and portfolio evolution.
• Assess portfolio strengths, gaps, risks, and opportunities to support decision-making and resource allocation.
• Lead portfolio-level trade-off discussions, balancing scientific opportunity, probability of success, patient impact, and commercial value.
• Translate scientific and market dynamics into actionable recommendations for senior leadership.
• Advise Oncology leadership on portfolio prioritization and capital allocation.
• Develop portfolio recommendations for governance committees and enterprise decision-making forums.
• Establish and maintain frameworks to improve consistency, rigor, and transparency in portfolio evaluations.
• Drive investment prioritization, development sequencing, indication expansion, and lifecycle optimization discussions.
• Support enterprise and PMT requests for assessments and valuations, critical portfolio reviews, and recommendations for senior executives.
• Integrate scientific, clinical, epidemiologic, access, policy, patient, competitive, and commercial insights into portfolio strategies.
• Monitor oncology trends and standards of care, and assess disruptive technologies, novel modalities, and future treatment paradigms for portfolio implications.
• Develop strategic perspectives on the future oncology landscape and implications for Pfizer.
• Lead commercial dashboards, reports, and scenario planning for senior leadership.
• Partner across functions to align stakeholders around portfolio priorities and lead visible cross-functional initiatives with enterprise-wide impact.
• Advance portfolio management capabilities, methodologies, and AI-enabled decision-support approaches.
• Partner with senior Oncology leaders to ensure commercial perspectives inform portfolio, early development, investment, and lifecycle decisions.
• Support preparation for governance forums, portfolio reviews, strategy discussions, development decision points, and investment prioritization meetings.
• Build relationships across global, regional, and local stakeholders to align on strategic choices, assumptions, implications, and execution priorities.
• Ensure heme strategies are integrated across disease-area, asset, launch, access, and regional considerations.
• Set priorities, accountabilities, and ways of working for matrix teams; foster accountability, collaboration, learning, and enterprise thinking.
• Develop team capabilities in scientific and competitive assessment, early commercial strategy, portfolio decision support, business cases, and executive communication.
• Provide guidance, feedback, and development opportunities to colleagues and mentor and develop team members.
• Use AI-enabled tools for scientific and competitive landscape synthesis, market insight generation, scenario development, portfolio analysis, and strategy-workstream efficiency.
• Apply AI-augmented approaches to accelerate analysis, identify patterns across complex data, and improve strategic output quality and consistency.
• Champion responsible and compliant AI-enabled approaches and build team capability in AI-enabled strategy and commercial decision support.
• Stay current on tools and practices that can strengthen portfolio strategy, commercial development, and launch-readiness decision-making.

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution.
• Paid vacation, holiday, and personal days.
• Paid caregiver, parental, and medical leave.
• Medical, prescription drug, dental, and vision coverage.
• Participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of base salary.
• Eligibility to participate in Pfizer’s share-based long-term incentive program.
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior