Global Commercial Strategy (GCS) Oncology: Senior Director, Portfolio Strategy

Pfizer • New York City, NY

9d • Hybrid

About The Position

The Senior Director, Oncology Portfolio Strategy is a senior strategic leader responsible for shaping Pfizer’s long-term Oncology portfolio strategy and investment agenda. The role leads development of commercial portfolio strategies across tumor types, modalities, and innovation platforms to support disciplined investment decisions that maximize patient impact and portfolio value. It translates scientific, clinical, commercial, competitive, and financial insights into enterprise-level recommendations and partners across Research, Development, Commercial, Medical, Access, Business Development, and Finance.

The Senior Director advises Oncology leadership on portfolio prioritization, resource allocation, external innovation assessments, and long-range strategic planning. The role also advances portfolio management frameworks, governance processes, and decision-support capabilities, including responsible AI-enabled approaches, to strengthen strategic decision-making. It leads cross-functional initiatives, supports governance and portfolio reviews, and mentors colleagues while fostering strategic thinking, innovation, and analytical rigor.

Requirements

• Bachelor’s degree required.
• 12+ years of successful, progressive experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, business development, strategy consulting, corporate strategy, or related fields.
• Experience in Oncology.
• Demonstrated experience leading enterprise-level strategic initiatives and influencing significant investment decisions.
• Experience leading highly visible, cross-functional initiatives in complex matrix organizations.
• Ability to synthesize scientific, clinical, commercial, competitive, and financial information to support portfolio prioritization and capital allocation decisions.
• Strong strategic, analytical, and financial acumen, including experience evaluating risk, uncertainty, and value creation across multiple opportunities.
• Track record of influencing senior leadership and driving alignment among diverse stakeholder groups.
• Excellent communication, facilitation, organizational, and executive-ready storytelling skills.
• Ability to influence and collaborate with peers, develop and coach others, and oversee and guide colleagues’ work to achieve meaningful outcomes and business impact.
• Discretion, sound judgment, and trustworthiness when handling confidential or sensitive organizational matters.
• Ability to thrive in ambiguity, make recommendations with incomplete information, and lead teams through evolving portfolio priorities.

Nice To Haves

• Advanced degree in business, life sciences, medicine, pharmacy, public health, or a related field.
• Experience developing long-range portfolio strategies across multiple disease areas, modalities, or therapeutic platforms.
• Experience supporting governance bodies, investment committees, or enterprise portfolio reviews.
• Demonstrated success shaping portfolio prioritization frameworks, resource allocation decisions, and strategic trade-off discussions.
• Experience assessing internal pipeline and external innovation opportunities, including licensing, partnerships, and acquisitions.
• Deep understanding of portfolio management principles, valuation methodologies, forecasting, and investment decision-making.
• Deep understanding of the oncology ecosystem, including evolving standards of care, emerging science, competitive dynamics, and future market evolution.
• Experience evaluating opportunities across multiple tumor types and mechanisms rather than a single disease area.
• Ability to connect scientific innovation with portfolio-level value creation and strategic differentiation.
• Experience advising senior executives on complex strategic decisions with significant business impact.
• Demonstrated ability to lead through ambiguity and navigate competing stakeholder priorities.
• Experience establishing strategic frameworks, processes, or capabilities that improve organizational decision-making.
• Comfort operating in an AI-enabled or AI-augmented environment; experience using AI tools to support strategy, synthesis, scenario planning, or analysis.
• Breadth of diverse leadership experiences and capabilities, including influencing and collaborating with peers, developing and coaching others, and guiding colleagues’ work.

Responsibilities

• Lead the development and evolution of Oncology portfolio strategy, identifying high-value opportunities across tumor types, mechanisms, modalities, and therapeutic platforms.
• Develop long-range portfolio scenarios and strategic roadmaps to inform investment priorities and portfolio evolution.
• Assess portfolio strengths, gaps, risks, and opportunities to support proactive decisions and resource allocation.
• Lead portfolio-level strategic trade-off discussions, balancing scientific opportunity, probability of success, patient impact, and commercial value.
• Translate complex scientific and market dynamics into actionable portfolio recommendations for senior leadership.
• Advise Oncology leadership on portfolio prioritization and capital allocation decisions.
• Develop portfolio recommendations for governance committees and enterprise decision-making forums.
• Establish and maintain frameworks that improve consistency, rigor, and transparency in portfolio evaluations.
• Drive enterprise discussions on investment prioritization, development sequencing, indication expansion, and lifecycle optimization.
• Support enterprise and portfolio management team requests for assessments and valuations, and develop recommendations for critical portfolio reviews and senior executive stakeholders.
• Integrate scientific, clinical, epidemiologic, access, policy, patient, competitive, and commercial insights into portfolio strategies.
• Monitor emerging oncology trends and standards of care; evaluate disruptive technologies, novel modalities, and future treatment paradigms for portfolio implications.
• Develop strategic perspectives on the evolution of the oncology landscape and its implications for Pfizer.
• Lead commercial dashboards, reports, and scenario planning to inform senior leadership.
• Partner across Research, Development, Medical, Commercial, Access, Portfolio Decision Analysis, Regulatory, Finance, and Business Development to align stakeholders around portfolio priorities.
• Lead highly visible, cross-functional strategic initiatives with enterprise-wide impact.
• Advance portfolio management capabilities, methodologies, and AI-enabled decision-support approaches.
• Serve as a trusted strategic thought partner and influencer across the Oncology organization; mentor and develop colleagues.
• Lead and influence complex, matrixed cross-functional teams and ensure the commercial perspective is incorporated into portfolio, early development, investment, and lifecycle decisions.
• Support preparation for governance forums, portfolio reviews, strategy discussions, development decision points, and investment prioritization meetings.
• Build trusted relationships with global, regional, and local stakeholders to align strategic choices, assumptions, implications, and execution priorities.
• Ensure hematology strategies are integrated across disease-area, asset, launch, access, and regional considerations.
• Set team priorities, accountabilities, and ways of working; foster accountability, collaboration, learning, enterprise thinking, and a high-performing team culture.
• Develop team capability in scientific and competitive landscape assessment, early commercial strategy, portfolio decision support, business case development, and executive communication; provide guidance, feedback, and development opportunities.
• Use AI-enabled tools for scientific and competitive landscape synthesis, market insight generation, scenario development, portfolio analysis, and strategy-workstream efficiency.
• Apply AI-augmented approaches to accelerate analysis, identify patterns across complex data sources, and improve the quality and consistency of strategic outputs.
• Champion responsible, compliant AI-enabled practices in hematology early commercial strategy, portfolio assessment, and decision support.
• Build team capability and confidence in AI-enabled strategy development, synthesis, and commercial decision support; stay current on tools and practices that can strengthen portfolio strategy, commercial development, and launch-readiness decisions.

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution.
• Paid vacation, holiday, and personal days.
• Paid caregiver, parental, and medical leave.
• Medical, prescription drug, dental, and vision coverage.
• Participation in Pfizer’s Global Performance Plan, with a bonus target of 22.5% of base salary.
• Eligibility to participate in Pfizer’s share-based long-term incentive program.
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior