Senior Director, Molecular Imaging Physicist

Bristol Myers Squibb • San Diego, CA

12d

About The Position

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/ The Sr. Director, Molecular Imaging Physicist will be responsible for applying their deep expertise in nuclear medicine, molecular imaging (including PET and SPECT instrumentation and quantitative analysis) to drive innovation and ensure the highest standards in both preclinical and clinical programs. The Sr. Director, Molecular Imaging Physicist will lead and coordinate imaging and dosimetry activities across multidisciplinary teams, oversee translational dosimetry analysis, support clinical studies and manage collaborations with internal stakeholders, external vendors, and scientific partners. The ideal candidate will execute conventional RPT physics approaches with ease, drive deep-learning based innovations with a passion to advance imaging technologies, contribute to protocol and strategy development, and provide technical support and training, all while championing quality practices and regulatory compliance in the adoption of novel radioisotopes and modeling approaches, including for alpha-emitting radiotherapeutics.

Requirements

• Advanced degree in Medical Physics, Molecular Imaging, Electrical Engineering, or related discipline, with didactic training in dosimetry-enabling image-quantification
• Minimum of 7 years of experience in industry in a cross-functional matrix environment.
• Minimum of 2 years of experience in radiopharmaceutical diagnostics and therapeutics development in oncology, experience with alpha-emitters strongly desired.
• Subject Matter Expert with extensive experience in radiopharmaceutical development for oncology, including theranostic pairs and alpha-emitter technologies, able to support all aspects of internal dosimetry analysis, including extensive experience with instrumentation (e.g. PET, SPECT, autoradiography), image reconstruction, and clinical applications as appropriate.
• Demonstrated ability to design, execute, and analyze dosimetry data from preclinical experiments as well as support clinical research involving conventional and advanced imaging innovations, leading translational dosimetry data collection and analysis, and ensuring data quality control and standardization processes aligned with current literature and global guidelines.
• Passion for advancing medical physics knowledge and pioneering innovative radiopharmaceutical technologies, including deep learning-based methods for image reconstruction and evaluation of novel radioisotopes.
• Familiarity with clinical scanner models and experience in developing imaging protocols, manuals, analysis plans and clinical study reports across phases 1 to 4 trials and providing technical expertise for supporting regulatory submissions.
• Technical proficiency with scanner and dosimetry software, image data processing, coding and/or simulation, modeling, and statistical tools such as 3D-RD-S, MIM, MIRDcalc, OLINDA, Torch, GATE, SIMIND, SAAM II, SimBiology, Python, C, C++, Matlab, R, SPSS, ITK-snap, 3D Slicer, Elastix, or deep learning-based image reconstruction algorithms.
• Proven track record in managing projects by coordinating cross-functional teams, aligning stakeholders, and delivering on corporate timelines in a multidisciplinary and dynamic environment.
• Ability to organize, prioritize, and work effectively with minimal supervision while adapting to a constantly changing environment; recognized leadership skills, professional ethics, integrity, and ability to maintain confidential information.
• Ability to leverage AI to drive programs, portfolios, or functional performance through prioritization and scaled adoption
• Strong communication skills with the ability to present and discuss complex imaging and dosimetry topics clearly and concisely to global scientific audiences, regulatory bodies, vendors, and internal stakeholders.
• Willingness to travel (up to 10-15%), including participation in conferences, industry events, and evening/weekend engagements as required.

Nice To Haves

• PhD
• Experience with radiopharmaceuticals as diagnostics and/or therapeutics in oncology and experience with alpha-emitters.
• Board certification in nuclear medicine physics or radiation protection.

Responsibilities

• Lead and coordinate all aspects of internal dosimetry and quantitative imaging analysis in the discovery and development of radiopharmaceutical imaging and/or therapeutic agents.
• Initiate, design, and execute imaging strategies for preclinical and clinical studies, including protocol development, imaging manuals, statistical analysis plans, and clinical trial reporting.
• Support advanced dosimetric analysis and modeling from imaging modalities (e.g., PET, SPECT, CT), including kinetic modeling, compartmental analysis, and physiologically-based pharmacokinetic modeling to assess drug uptake, distribution, and translation from animal to human.
• Oversee and optimize image data quality control, including standardization processes, calibration, and quality assurance, aligned with current industry guidelines and literature.
• Innovate and implement new imaging technologies, reconstruction algorithms, and modeling approaches to enhance diagnostic accuracy, therapeutic efficacy, and radiopharmaceutical development, including novel radioisotopes (e.g. alpha-emitters).
• Manage and support relationships with imaging and dosimetry vendors, CROs, external investigators, and government agencies.
• Provide expert technical support, training, and problem-solving solutions to cross-functional teams throughout the organization.
• Contribute to regulatory activities and the advancement of medical physics knowledge in radiopharmaceuticals.
• Communicate complex imaging and dosimetry topics clearly and concisely to internal and external scientific stakeholders.
• Organize, prioritize, and deliver on corporate timelines in a dynamic, multidisciplinary team environment with minimal supervision.
• Maintain professional ethics, integrity, leadership, and confidentiality, and stay current with global dosimetry guidelines and advances in radiopharmaceutical science.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree