Senior Director, Cardiovascular and Metabolic Diseases, Clinical Pharmacology Modeling and Simulation

GSK • Durham, NC

7d • $222,750 - $371,250 • Hybrid

About The Position

GSK is recruiting a senior clinical pharmacology leader for its newly established Clinical Pharmacology and Quantitative Medicine (CPQM) organisation. The role focuses on applying Model-Informed Drug Development (MIDD) and clinical pharmacology across the drug development lifecycle, from first-in-human studies through regulatory filing and lifecycle management. It provides clinical pharmacology strategy and evidence-generation input to support development programs, optimal dosing, faster development, regulatory positioning, and business development opportunities.

The position coordinates clinical pharmacology modeling and simulation activities across the Respiratory, Immunology & Inflammation Research Unit (RIIRU) portfolio and works with CPQM colleagues and cross-functional partners to shape portfolio and disease-area strategy. It approves study designs, analyses, interpretations, reports, and regulatory documents, and contributes to regulatory-ready evidence and labeling. The role also builds internal and external scientific partnerships and represents GSK through publications, conference presentations, and participation in scientific and regulatory forums.

The posting states that this is a hybrid role. For candidates located at the Stevenage site, the position will temporarily be based there, with a planned relocation to Cambridge, UK, currently proposed for early 2029. The posting also provides a US annual base salary range of $222,750–$371,250 for new hires based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, plus an annual bonus and eligibility for a share-based long-term incentive program.

Requirements

• PhD, MD, or PharmD.
• At least 8 years of industry experience in clinical pharmacology, modeling/simulation, and drug development, applying these disciplines to practical problems in the pharmaceutical industry.
• Experience in pharmacometrics and its application to clinical questions in drug development.
• Experience working with senior stakeholders in a cross-functional environment.
• Experience in Cardiovascular and Metabolic Diseases therapy areas.

Nice To Haves

• Experience collaborating in multidisciplinary teams, communicating effectively, taking personal accountability, and delivering results on time.
• Sound judgment in complex situations and adaptability to changing business needs while prioritizing multiple tasks.
• A strong track record of implementing MIDD approaches to accelerate patient access to novel therapies and expand therapeutic indications of marketed drugs.
• Drive and learning agility to build knowledge of drug-disease systems, symptom progression, standard of care, and trial design.

Responsibilities

• Develop and implement Model-Informed Drug Development and clinical pharmacology evidence strategies to de-risk and accelerate programs, support optimal dosing and regulatory positioning, and contribute to business development opportunities.
• Coordinate clinical pharmacology modeling and simulation activities across and above assets within RIIRU, ensuring consistency with global CPMS/CPQM priorities and senior leadership.
• Work with CPQM colleagues and cross-functional partners to shape RIIRU portfolio and disease-area plans and maximize scientific and operational impact.
• Approve study designs, analyses, interpretations, reports, and clinical pharmacology regulatory documents across the RIIRU portfolio.
• Draft and review clinical pharmacology regulatory content to support timely approvals and optimal labeling.
• Stay current with FDA, EMA, CDE, PMDA, and ICH expectations and incorporate regulatory considerations and best practices into study design and MIDD strategies.
• Capture and share lessons learned and trends to continuously improve CPMS contributions to the R&D pipeline.
• Build and maintain partnerships across CPQM, the CPMS community of practice, and functions including AI/ML, biomarkers, biostatistics, clinical operations, data science, computational biology, and real-world evidence.
• Raise GSK’s profile in MIDD, clinical pharmacology, QSP, and AI/ML integration through publications, conference presentations, and participation in scientific and regulatory forums.

Benefits

• Annual bonus
• Eligibility to participate in a share-based long-term incentive program, dependent on role level
• Health care and other insurance benefits for employees and family
• Retirement benefits
• Paid holidays
• Vacation
• Paid caregiver, parental, and medical leave

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree