Director, Cardiovascular and metabolic diseases, Clinical Pharmacology Modeling and Simulation

GSK • Durham, NC

7d • $188,100 - $313,500

About The Position

GSK’s Department of Clinical Pharmacology Modelling & Simulation in Respiratory and Inflammation is recruiting a Director-level clinical pharmacologist with cardiovascular and metabolic disease expertise. The role is part of the newly established Clinical Pharmacology and Quantitative Medicine organisation, which aims to be a centre of excellence in Model-Informed Drug Development by integrating clinical pharmacology, digital medicine, translational imaging, and mechanistic and systems modelling.

The Director will lead the end-to-end application of Model-Informed Drug Development across the drug development lifecycle, from first-in-human studies through filing and lifecycle management, and provide clinical pharmacology strategy and evidence-generation input. The position works across respiratory, inflammation, neurodegeneration, and emerging areas, and supports business development opportunities. The role reports directly to the Respiratory, Immunology & Inflammation Research Unit.

For candidates based at the Stevenage site, the role will temporarily be based there. GSK plans to relocate its offices to Cambridge, UK, with the role’s location subsequently changing to Cambridge in accordance with company timelines. The relocation is currently proposed to take effect by early 2029.

Requirements

• PhD, MD, or PharmD.
• At least 5 years of industry experience in clinical pharmacology, modelling and simulation, and drug development, applying these disciplines to practical pharmaceutical industry problems.
• Experience in pharmacometrics and its application to clinical questions in drug development.

Nice To Haves

• Experience in cardiovascular and metabolic diseases.
• Experience collaborating in multidisciplinary teams, communicating effectively, and taking personal accountability for timely delivery of results.
• Evidence of sound judgment in complex situations and adaptability to changing business needs while prioritizing multiple tasks.
• Experience working with senior stakeholders in a cross-functional environment.
• A track record of implementing Model-Informed Drug Discovery and Development approaches to accelerate patient access to novel therapies and expand therapeutic indications of marketed drugs.
• Drive and learning agility to build knowledge of a drug-disease system, symptom progression, standard of care, and trial design.

Responsibilities

• Develop and implement robust Model-Informed Drug Development and clinical pharmacology evidence strategies to de-risk and accelerate programs, supporting faster development, optimal dosing, regulatory positioning, and business development opportunities.
• Draft and review clinical pharmacology regulatory content to support timely approvals and optimal labelling.
• Maintain current knowledge of FDA, EMA, CDE, PMDA, and ICH expectations and incorporate regulatory considerations and best practices into study design and MIDD strategies.
• Collaborate with Clinical Pharmacology and Quantitative Medicine colleagues in digital medicine, translational imaging, MIDD, and mechanistic and systems modelling.
• Work with cross-functional partners in areas including biology, data science, and computational biology, and build networks with AI/ML, biomarkers, biostatistics, clinical operations, and real-world evidence teams to embed quantitative approaches in asset-level decisions.
• Maintain networks and share best practices in the Clinical Pharmacology Modelling & Simulation community of practice.
• Raise GSK’s profile in MIDD, clinical pharmacology, quantitative systems pharmacology, and AI/ML integration through publications, conference presentations, and participation in scientific and regulatory forums.
• Contribute to influencing method adoption and regulatory dialogue.

Benefits

• Annual bonus.
• Eligibility to participate in a share-based long-term incentive program, dependent on role level.
• Health care and other insurance benefits for employees and their families.
• Retirement benefits.
• Paid holidays.
• Vacation.
• Paid caregiver, parental, and medical leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree