Director, Cardiovascular and metabolic diseases, Clinical Pharmacology Modeling and Simulation

GSK • Waltham, MA

6d • $188,100 - $313,500

About The Position

GSK’s Clinical Pharmacology Modelling & Simulation department is recruiting a Director-level Clinical Pharmacologist with cardiovascular and metabolic disease expertise. The position is part of the newly established Clinical Pharmacology and Quantitative Medicine (CPQM) organisation, which aims to be a centre of excellence in Model-Informed Drug Development (MIDD) by integrating clinical pharmacology, digital medicine, translational imaging, and mechanistic and systems modelling.

The Director will lead the end-to-end application of MIDD across the drug development lifecycle, from first-in-human studies through filing and lifecycle management, and contribute clinical pharmacology strategy and evidence generation. The role works across drug development programs and therapeutic areas, with the goal of accelerating development, optimizing dosing, strengthening regulatory positioning, and supporting business development opportunities. It also includes scientific leadership and external engagement through publications, conference presentations, and participation in scientific and regulatory forums.

For candidates based at the Stevenage site, the role will initially be based there. GSK plans to relocate its offices to Cambridge, UK, with the relocation currently proposed to take effect by early 2029; the role’s location will subsequently change in accordance with company timelines.

Requirements

• PhD, MD, or PharmD.
• At least 5 years of industry experience in clinical pharmacology, modelling and simulation, and drug development, applying these disciplines to practical pharmaceutical-industry problems.
• Experience in pharmacometrics and its application to clinical questions in drug development.

Nice To Haves

• Experience in cardiovascular and metabolic diseases.
• Demonstrated ability to collaborate in multidisciplinary teams, communicate effectively, and take personal accountability for timely delivery of results.
• Evidence of sound judgment in complex situations and adaptability to changing business needs while prioritizing multiple tasks.
• Experience working with senior stakeholders in a cross-functional environment.
• Track record of implementing MIDD approaches to accelerate patient access to novel therapies and expand therapeutic indications of marketed drugs.
• Drive and learning agility to build knowledge of a drug-disease system, symptom progression, standard of care, and trial design.
• Skills in drug design, drug development, drug discovery processes and research, medication safety, molecular modelling, pharmaceutical regulatory compliance and sciences, pharmacodynamics, pharmacokinetics, pharmacology, pharmacometrics, pharmacovigilance, study design, and target validation.

Responsibilities

• Develop and implement Model-Informed Drug Development and clinical pharmacology evidence strategies to de-risk and accelerate programs.
• Apply MIDD and clinical pharmacology approaches to support faster development, optimal dosing, stronger regulatory positioning, and business development opportunities.
• Draft and review clinical pharmacology regulatory content to support timely approvals and optimal product labelling.
• Maintain current knowledge of FDA, EMA, CDE, PMDA, and ICH expectations and incorporate regulatory considerations and best practices into study design and MIDD strategies.
• Collaborate with CPQM colleagues, including digital medicine, translational imaging, MIDD, and mechanistic and systems modelling specialists, as well as cross-functional partners.
• Build networks with functions such as AI/ML, biomarkers, biostatistics, clinical operations, data science, computational biology, and real-world evidence to embed quantitative approaches in asset-level decision-making.
• Maintain networks and share best practices within the CPMS community of practice.
• Raise GSK’s profile in MIDD, clinical pharmacology, QSP, and AI/ML integration through publications, conference presentations, and participation in scientific and regulatory forums.
• Contribute to regulatory dialogue and influence adoption of scientific methods.

Benefits

• Annual bonus.
• Eligibility to participate in a share-based long-term incentive program, dependent on role level.
• Health care and other insurance benefits for employees and families.
• Retirement benefits.
• Paid holidays.
• Vacation.
• Paid caregiver, parental, and medical leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree