Senior Biostatistician

Mass General Brigham•Somerville, MA

2d•Hybrid

About The Position

Mass General Brigham (MGB) is a leading not-for-profit healthcare system dedicated to advancing patient care, research, teaching, and community service. The Neurological Clinical Research Institute (NCRI) at Massachusetts General Hospital (MGH), the largest research hospital in the United States, is seeking a qualified Senior Biostatistician. This role is within the NCRI Biostatistics group, which collaborates closely with MGH Biostatistics and Harvard University's TH Chan School of Public Health. The Senior Biostatistician will engage in hands-on, cross-disciplinary work within a mission-driven setting, contributing to the design, conduct, and analysis of research focused on neurodegenerative diseases. The position offers a unique opportunity to work on academic and FDA-regulated clinical trials, observational studies, and registries, utilizing rigorous statistical methods and programming in SAS and R. The ideal candidate will be self-motivated, detail-oriented, and thrive in a fast-paced, solution-oriented environment, taking ownership of projects and collaborating effectively with diverse teams across academia, industry, and regulatory bodies.

Requirements

Masters (MS/MA) in Biostatistics, Statistics, Epidemiology, Computer Science, Mathematics, Engineering, Life Science, or related field.
3+ years of professional experience in academic medicine or pharmaceutical industry setting.
Proficiency with SAS or R.
Experience supporting studies in all phases from design through publication.
Ability to explain statistical concepts to non-statistical collaborators.
Exceptional attention to detail and organizational skills.
Strong ability to identify and resolve issues, manage competing priorities, and meet timelines consistently.
Self-motivated with a commitment to producing high quality, on-time deliverables and a strong sense of ownership.
Excellent written and verbal communication skills, with the ability to effectively collaborate with multidisciplinary teams.
Team-oriented mindset with a commitment to fostering collaboration and building productive working relationships.
Strong background in statistical programming using SAS or R.
Strong communication skills, including proficiency in written and spoken English.
Excellent attention to detail.
Experience in supporting studies in all phases, from design through publication.
Ability to explain statistical concepts to non-statistical collaborators.

Responsibilities

Develop statistical analysis plans for clinical trials, observational studies, and other biomedical research projects.
Conduct statistical analyses for clinical trials, observational studies, and registry data, including analyses of longitudinal outcomes, survival data, and other complex study designs using appropriate statistical models (e.g., mixed-effects models, survival models).
Begin to oversee biostatisticians and/or statistical programmers.
Generate reports of study progress, including reports for data and safety monitoring boards, and assist in the design of these reports.
Develop programs and guide efforts to perform robust data manipulation and error detection to ensure data integrity.
Assist in power calculations, determine sample size requirements, and advise on experimental design.
Assist and contribute to statistical analyses for scientific manuscripts, including drafting statistical methods sections, preparing tables and figures, and collaborating with investigators on interpretation and presentation of results.
Assist in the design of clinical studies and review protocols for statistical considerations.
Provide statistical guidance for grants and other funding proposals.
Engage in professional development opportunities.
Assist in hiring, onboarding, training, and mentoring statistical programmers and biostatisticians.