Senior Associate Scientist - Assay Development

Regeneron Pharmaceuticals • Tarrytown, GA

3d • $80,300 - $131,100 • Onsite

About The Position

Regeneron’s Assay Development Group in Tarrytown, New York, is seeking a Senior Associate Scientist to develop, optimize, and execute mass spectrometry-based methods for quantifying and investigating biologics, siRNAs, and novel antibody conjugates. The role generates high-quality data and communicates findings that advance programs across the pipeline. It offers cross-functional work in a fast-paced, science-driven environment, applying technical expertise, creativity, and scientific judgment to address complex challenges and support the development of therapies.

The scientist performs hands-on laboratory work, analyzes and interprets complex datasets, maintains electronic laboratory notebook records, and presents findings to technical, departmental, leadership, and cross-functional audiences. The role also manages concurrent assays and projects, evaluates emerging technologies and assay formats, maintains GLP-compliant practices and documentation for assay validations in accordance with FDA regulations and company SOPs, and collaborates across Bioanalytical Sciences, Regeneron, and CROs.

Requirements

• Bachelor's or Master's degree in Biophysics, Biochemistry, Chemistry, Engineering, or a related field.
• At least 3 to 6 years of relevant industry experience appropriate to level.
• Ability to independently design experiments, analyze and interpret data, draw sound conclusions, and communicate findings to technical and cross-functional audiences.
• Hands-on experience operating and troubleshooting HPLC/UHPLC and mass spectrometry instrumentation, including QQQ, Q-TOF, and Orbitrap.
• Strong initiative, scientific curiosity, organization, and ability to prioritize multiple projects with minimal supervision in a collaborative environment.
• Excellent oral and written communication skills and commitment to timely, compliant laboratory documentation.

Nice To Haves

• Experience developing and executing quantitative mass spectrometry assays to support PK, PD, and biomarker bioanalysis for large-molecule therapeutic modalities.
• Experience with KingFisher systems, high-throughput extraction, and other automated sample preparation platforms.
• Experience preparing samples for immunoaffinity capture, SPE, and other fit-for-purpose bioanalytical approaches in different biological matrices.
• Experience developing novel bioanalytical assay platforms or introducing new assay formats and emerging technologies.
• Understanding of protein/antibody structure-function relationships and PK/PD principles.
• Biopharmaceutical industry experience, including collaboration with cross-functional teams and external partners such as CROs.
• Prior experience in bioanalytical (regulated) assay execution and a collaborative team mindset.

Responsibilities

• Optimize, troubleshoot, and execute quantitative mass spectrometry assays for biomarkers, therapeutic proteins, peptides, siRNAs, antibody conjugates, small molecules, and linker-payloads.
• Perform hands-on laboratory work using HPLC/UHPLC, mass spectrometry, KingFisher-based purification or extraction, and related quantitation and characterization techniques.
• Analyze and interpret complex datasets, maintain accurate electronic laboratory notebook records, and present findings to technical, departmental, leadership, and cross-functional audiences.
• Manage multiple assays and projects concurrently and evaluate emerging technologies and assay formats.
• Maintain GLP-compliant laboratory practices and documentation for assay validations in accordance with FDA regulations and company SOPs.
• Collaborate within Bioanalytical Sciences, across Regeneron, and with CROs to troubleshoot challenges, align priorities, and support program execution.

Benefits

• Competitive and comprehensive total rewards package, which may include annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (including medical, dental, vision, life, and disability), paid time off, and family support benefits.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior