Senior Associate Scientist

Bristol Myers Squibb • San Diego, CA

3d • Onsite

About The Position

The Protein Homeostasis Thematic Research Center at BMS is a fundamental Oncology research engine delivering oncology and hematology therapeutics to patients. The TRC has a major focus on exploiting BMS’ expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable.

Requirements

• Bachelor’s Degree 4+ years of academic and / or industry experience Or Master’s Degree 2+ years of academic and / or industry experience
• Proficiency in Microsoft Office Suite (Word, Excel, PowerPoint)

Nice To Haves

• Hands-on experience with mammalian cell culture, including standard 2D and preferably 3D culture systems
• Proficiency in plate-based cell assays, including CTG, apoptosis, and Incucyte imaging platforms
• Experience with transfection and viral transduction techniques, including overexpression and CRISPR-based knockout approaches
• Familiarity with protein detection methods, including Western blotting; experience with WES/JESS ProteinSimple is a plus
• Excellent organizational skills and attention to detail, with a demonstrated ability to maintain accurate and thorough laboratory records
• Eagerness to learn and apply new techniques, instrumentation, and methodologies
• Ability to work both independently and collaboratively as part of a multidisciplinary team
• experience with GraphPad Prism and FlowJo is a plus

Responsibilities

• Develop, maintain, and passage mammalian cell lines and patient derived organoids, including the generation of overexpressing and knockout lines, for use in screening and functional assays
• Design and execute assays to assess cell growth, apoptosis, cell cycle progression, and protein expression
• Manage cryopreservation of tissues and cell lines
• Independently analyze and interpret data and present results at project team meetings, group meetings, etc.
• Collaborate with colleagues in other functional areas including translational research, informatics and chemistry to pursue target validation experiments and support drug discovery efforts
• Maintain accurate electronic laboratory notebooks in a timely fashion and prepare technical reports, summaries, protocols, etc.
• Stay current with emerging AI tools and best practices relevant to drug discovery and contribute to the adoption of innovative computational approaches within the team
• Assist in laboratory operation management duties

Benefits

• Medical, pharmacy, dental, and vision care.
• Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees))
• 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior