Scientist 3, Lung Biology & Inflammation
About The Position
The Department of Immunology at Genentech is seeking a Scientist with deep expertise in lung biology and immunology to uncover novel therapeutic targets for respiratory diseases. The role leads research projects investigating cellular and molecular mechanisms underlying lung injury, chronic inflammation, and tissue repair, and advances research-stage programs toward early clinical development by generating proof-of-concept data. The Scientist uses in vitro and in vivo models and state-of-the-art technologies to evaluate novel molecules and targeted delivery systems, investigates inflammatory lung disease pathogenesis and therapeutic mechanisms of action, and drives pipeline research alongside exploration of new biologies and pathways for target discovery. The role collaborates across immunology, human genetics, biomarker discovery, and early clinical development, and presents findings at scientific meetings. The position is based in South San Francisco with a hybrid schedule requiring three days per week on campus. No relocation benefits are available.
Requirements
- PhD in immunology, stem cell biology, molecular biology, biochemistry, or a related field.
- Demonstrated record of high-quality publications.
- Deep understanding of lung biology, particularly chronic respiratory diseases, tissue remodeling or regeneration, or host-microbe interactions.
- Strong hands-on molecular biology expertise, including cellular transfections, gene expression profiling, precision genome editing, and targeted RNA delivery technologies.
- Hands-on experience isolating primary cells from human or mouse tissues, conducting in vitro immunological assays, and performing multidimensional flow cytometry.
- Track record of independently designing, executing, troubleshooting, and interpreting complex experiments leading to first-author publication(s) in top-tier journals.
Nice To Haves
- Experience with complex in vitro systems, including airway or alveolar organoids, air-liquid interface (ALI) 3D cultures, or organ-on-a-chip technologies.
- Experience with targeted therapeutic delivery of nucleic acid modalities, such as mRNA, siRNA, or ASOs, using viral or non-viral vectors.
- Experience with computational data analysis, including scRNA-seq, spatial transcriptomics, or mining public or clinical datasets.
Responsibilities
- Lead projects investigating cellular and molecular mechanisms underlying lung injury, chronic inflammation, and tissue repair.
- Advance novel research-stage programs into early clinical development by generating robust proof-of-concept data.
- Use in vitro and in vivo models and state-of-the-art technologies to evaluate novel molecules and targeted delivery systems.
- Investigate the pathogenesis of inflammatory lung diseases and identify the mechanism of action of therapies.
- Drive pipeline research while exploring new biologies and pathways for target discovery.
- Collaborate across immunology, human genetics, biomarker discovery, and early clinical development.
- Present research findings at intra- and inter-departmental scientific meetings.
Benefits
- A discretionary annual bonus may be available based on individual and Company performance.
- The position qualifies for company benefits detailed at the provided link; specific benefits are not listed.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
