Scientist 3, Lung Biology & Inflammation
About The Position
Genentech’s Department of Immunology is seeking a Scientist with expertise in lung biology and immunology to discover therapeutic targets for respiratory diseases. The role leads research into cellular and molecular mechanisms of lung injury, chronic inflammation, and tissue repair, and advances research-stage programs toward early clinical development by generating proof-of-concept data. The Scientist uses in vitro and in vivo models and state-of-the-art technologies to evaluate molecules and targeted delivery systems, investigates inflammatory lung disease mechanisms and therapeutic mechanisms of action, and pursues both pipeline research and new target-discovery biology. The role collaborates across immunology, human genetics, biomarker discovery, and early clinical development, and presents findings at scientific meetings. The position is based in South San Francisco and follows a hybrid schedule with three days per week on campus. Relocation benefits are not available.
Requirements
- PhD in immunology, stem cell biology, molecular biology, biochemistry, or a related field.
- Demonstrated record of high-quality publications.
- Deep understanding of lung biology, particularly chronic respiratory diseases, tissue remodeling or regeneration, or host-microbe interactions.
- Strong hands-on molecular biology expertise, including cellular transfections, gene expression profiling, precision genome editing, and targeted RNA delivery technologies.
- Hands-on experience isolating primary cells from human or mouse tissues, conducting in vitro immunological assays, and performing multidimensional flow cytometry.
- Ability to independently design, execute, troubleshoot, and interpret complex experiments, with first-author publication(s) in top-tier journals.
Nice To Haves
- Experience with complex in vitro systems such as airway or alveolar organoids, air-liquid interface (ALI) 3D cultures, or organ-on-a-chip technologies.
- Experience with targeted therapeutic delivery of nucleic acid modalities such as mRNA, siRNA, or ASOs using viral or non-viral vectors.
- Experience with computational data analysis, including scRNA-seq, spatial transcriptomics, or mining public or clinical datasets.
Responsibilities
- Lead projects investigating cellular and molecular mechanisms underlying lung injury, chronic inflammation, and tissue repair.
- Advance novel research-stage programs into early clinical development by generating robust proof-of-concept data.
- Use in vitro and in vivo models to evaluate novel molecules and targeted delivery systems.
- Investigate the pathogenesis of inflammatory lung diseases and identify mechanisms of action for therapies.
- Drive pipeline research and explore new biology and pathways for target discovery.
- Collaborate across immunology, human genetics, biomarker discovery, and early clinical development.
- Present research findings at intra- and inter-departmental scientific meetings.
Benefits
- A discretionary annual bonus may be available based on individual and Company performance.
- The position qualifies for company benefits described at the linked benefits information.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
