Scientist - Viral Vector Downstream Process Development

Eurofins USA PSS Insourcing Solutions•Boston, MA

1d•Onsite

About The Position

We are seeking a highly skilled, passionate, and motivated scientist to join our Downstream Process Development team. This role will support downstream unit operations and pilot-scale manufacturing campaigns. The ideal candidate will have experience with AAV purification techniques, with skills in data analysis and reporting data. The successful candidate will have a desire to succeed at the highest level to develop gene therapies for patients.

Requirements

B.S. in life sciences with 4-6 years of industry experience or M.S. in life sciences with 2-3 years of industry experience in downstream bioprocessing.
Previous experience in downstream unit operations (chromatography, filtration, centrifugation).
Hands-on experience with chromatography techniques including affinity chromatography and IEX.
Demonstrate a good understanding of tangential flow filtration (TFF) techniques.
Experience with AAV, lentivirus, or other viral vector purification.
Knowledge of small and pilot scale process development.
Demonstrate critical thinking, be self-motivated, accountable, detail-oriented, have excellent organization and communication skills, and demonstrate the ability to work both independently and as a member of a team.
Ability to work effectively with minimal supervision after initial training.
Ability to troubleshoot and interpret experimental results and effectively summarize and present conclusions.
Ability to work in a laboratory environment and handle occasional light to moderate lifting (up to ~50 lbs).
Authorization to work in the United States indefinitely without restriction or sponsorship.

Nice To Haves

Basic knowledge of analytical techniques for protein/viral vector characterization.
Knowledge of aseptic techniques and cell culture.
Familiarity with Unicorn software.
Familiarity with statistical analysis software (JMP, Minitab).
Exposure to process automation and single-use technologies.
Strong desire to learn new techniques and a willingness to provide upstream cross-training support.

Responsibilities

Execute and troubleshoot downstream purification unit operations, including affinity chromatography, tangential flow filtration (TFF), ion exchange chromatography, and ultracentrifugation.
Perform buffer preparation, sample collection, and in-process testing.
Maintain detailed laboratory notebooks and generate technical reports summarizing experimental findings.
Assist in pilot-scale manufacturing campaigns.
Execute batch records with close attention to detail.
Perform equipment setup, cleaning, and troubleshooting for pilot-scale unit operation.