Scientist/Sr. Scientist, Molecular Biology
About The Position
As a Scientist or Senior Scientist in Molecular Biology, you will play an important scientific role in our new Molecular Platform Development organization, driving high-throughput vector design and molecular cloning in support of biologics drug discovery. You will help build foundational molecular biology capabilities that enable display technologies, molecular interaction studies, and structural biology across the organization, at the inception of our new Cambridge, MA research center. This role suits a scientist with strong technical expertise in vector design, molecular cloning, and cell line engineering, scientific curiosity, and a desire to grow in scope and responsibility.
Requirements
- PhD in Molecular Biology, Cell Biology, Biochemistry, or a related field preferred (postdoctoral training preferred); candidates with a BS/MS and significantly more relevant industry experience will also be considered
- 2+ years of relevant post-degree experience in vector design, molecular cloning, and cell line engineering (Scientist); 4+ years (Senior Scientist)
- Expertise in high-throughput vector design and molecular cloning workflows (e.g., Golden Gate, Gibson assembly) to support rapid construct generation
- Experience generating challenging target classes, such as GPCRs and other multi-pass transmembrane proteins, receptor-Fc fusions, and biotinylated bait antigens
- Experience with genome editing and engineering approaches (e.g., lentiviral transduction, CRISPR-Cas9) for generation of engineered and target-expressing cell lines
- Strong technical expertise in vector design, molecular cloning, and cell line engineering
- Scientific curiosity and sound judgment
- Ability to thrive in a collaborative, multidisciplinary environment
- Motivated to help build foundational capabilities that enable multiple discovery platforms
- Ability to communicate scientific data and concepts clearly
- Ability to work effectively across cross-functional project teams
Nice To Haves
- Hands-on experience with cell culture and expression scaling (e.g., transient to stable systems, shake flask to bioreactor) is a plus
Responsibilities
- Design and construct expression vectors at high throughput to support recombinant protein expression, engineered cell line generation, and target reagent production across discovery programs
- Generate constructs and reagents for challenging target classes, including GPCRs and other multi-pass transmembrane proteins, receptor-Fc fusions, and biotinylated bait antigens
- Engineer mammalian and/or other host cell lines using contemporary molecular biology and genome engineering approaches (e.g., lentiviral transduction, CRISPR-Cas9)
- Support generation of target bait proteins and/or target-expressing cell lines to enable yeast, phage, and mRNA display selection campaigns and molecular interaction studies
- Support generation of constructs and cell lines for structural biology workflows, including protein production for crystallography, cryo-EM, and related structural methods
- Apply cell line engineering expertise to support development of in vitro pharmacology assays, including reporter and target-expressing cell lines for functional and binding assays
Benefits
- Salary Range: $125,000 - $170,000
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
