TEMP - Scientist, Immunology
About The Position
Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis and uterine fibroids, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. As part of the immunology Research Team, the individual will contribute to the assessment of novel therapeutic approaches to target autoimmunity and inflammation in immunology diseases. We are seeking a highly motivated, dedicated and collaborative scientist with knowledge and expertise in cellular and molecular immunology, with experience in antibody/small molecule drug discovery. The successful candidate will work as part of a highly team-oriented and collaborative group. The focus of this position will be to support the progression of multiple drug discovery projects in the Neuroimmunology space, by independently designing, performing, and validating key in vitro cell-based functional assays. The candidate will also perform experiments to understand the mechanism of action of drug candidates, and present data to cross-functional teams.
Requirements
- BS/BA in degree in biology, molecular and cellular immunology, or a related biological area and 2+ years of relevant experience OR MS/MA degree and industry experience preferred, immunology degree/background preferred OR PhD degree and relevant experience, industry experience preferred, immunology degree/background preferred
- Robust experience with whole blood, PBMC, T cells, and immune cell-based in vitro assays, hands-on experience in Treg assays is a plus
- Experience in RNAseq and data analysis independently is a plus
- Expertise in cell culture and aseptic technique, involving both immortalized cell lines and primary human/murine cells
- Experience in immunoassays (ELISA, MSD) and molecular biology techniques (mRNA isolation, qPCR)
- Experience with multicolor flow cytometric analysis and multiplex MSD is a must to have
- Able to explain the process behind data generated and the implications of the results
- Strong knowledge of one or more scientific disciplines, especially immunology
- Strong knowledge of scientific principles, methods, and techniques, and demonstrated ability to work with a variety of laboratory equipment/tools
- Excellent communication, problem-solving, and analytical thinking skills
- Ability to work as part of a cross-functional team, and present data and concepts clearly and concisely
- Demonstrated ability to meet multiple deadlines with a high degree of accuracy and efficiency, and experience prioritizing multiple projects is a plus
Nice To Haves
- Hands-on experience in Treg assays is a plus
- Experience in RNAseq and data analysis independently is a plus
- Experience prioritizing multiple projects is a plus
Responsibilities
- Designing and performing experiments to support scientific activities and project goals
- Separation of human PBMC from whole blood or leukopak, as well as the isolation of primary human leukocyte populations (T cells, CD4+ T cells, DCs) for downstream assays
- Maintain cell lines and primary cell cultures
- Perform immunological assays including lymphocyte proliferation, activation, cytokine secretion, and differentiation
- Perform basic molecular biology assays, including mRNA isolation, Taqman qPCR
- Flow cytometric analysis of immune cell subsets and analysis of data
- Perform immunoassays (MSD, ELISA, etc) for analysis of soluble proteins in cell supernatants/murine plasma
- Maintains and updates SOPs and electronic lab notebook and writes data summaries for experiments conducted
- Present data and findings to cross-functional project teams
- Provides training and/or supervision to junior staff, as needed
- Other duties as assigned
Benefits
- We are committed to building a workplace of belonging, respect, and empowerment
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
