Scientist, Immunology Cell Therapy Discovery (In Vitro Focus)
About The Position
AstraZeneca is a science-led biopharmaceutical company committed to transforming patient outcomes. We seek a curious, collaborative Scientist to advance novel cell therapies for autoimmune and immunology indications. This hands-on research role centers on in vitro work and cross-functional collaboration across our discovery teams. The role involves designing, optimizing, and executing in vitro assays to identify and validate cell therapy targets for autoimmune and inflammatory diseases. It requires applying expertise with primary human cells, multiplex flow cytometry, cytokine detection, and assay development to generate impactful data and move programs from discovery to translation. The Scientist will work closely with cross-functional groups to ensure rigorous science and timely milestones.
Requirements
- MS with 3+ years, or BS with 5+ years industry experience in immunology, autoimmunity, cell therapy, or related field
- Primary human cell culture, including functional immune cell-based assays and co-culture systems
- Multi-color flow cytometry and immunophenotyping
- Multiplex cytokine detection assays
- Assay development and optimization
- Experience with engineered cell products (e.g., T cell subsets, CAR-based modalities)
- Familiarity with target discovery and CAR T transduction and/or gene editing
- Strong experimental design, analysis, and interpretation
- Proficiency with common analysis tools (FlowJo, Prism)
- Ability to integrate complex datasets to guide decisions
- Demonstrated independence and adaptability in a dynamic environment
- Excellent record-keeping and reliable delivery to timelines
- Clear, concise written and verbal communication
- Proven ability to communicate complex scientific concepts across multidisciplinary teams
Nice To Haves
- Familiarity with in vitro model systems for autoimmune and inflammatory conditions, such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease, etc.
- Experience in pharmaceutical or biotech drug discovery and development
Responsibilities
- Develop and run primary cell-based assays and co-culture systems
- Apply multiplex flow cytometry, cytokine detection, and advanced experimental design to validate targets and characterize engineered cell therapies (e.g., T cells, CAR-based modalities)
- Apply a rigorous, data-driven approach to experimental design and decision-making
- Utilize analysis tools like FlowJo, OMIQ, and Prism
- Work with engineering, genomics, translational science, and clinical teams
- Communicate plans and findings clearly across groups and to leadership
- Foster a collegial and collaborative lab environment
- Maintain precise experimental documentation
- Collaborate on project planning, track progress, and focus on experimental efficiency to achieve milestones
Benefits
- Short-term incentive bonus opportunity
- Eligibility to participate in our equity-based long-term incentive program
- Qualified retirement program [401(k) plan]
- Paid vacation and holidays
- Paid leaves
- Health benefits including medical, prescription drug, dental, and vision coverage
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Mid Level
