Scientist I, In Vitro Pharmacology

Flagship Pioneering, Inc.•Boston, MA

1d•$100,000 - $126,500

About The Position

Abiologics, Inc. is seeking a highly motivated, broadly skilled cell biologist and assay developer to join their growing Pharmacology team. In this role, the successful candidate will be responsible for developing and executing biochemical and cell-based assays to support the progression of Abiologics’ pipeline. Occasionally, this individual may contribute to in vivo and ex-vivo pharmacology activities to progress projects and the platform. In addition, this role will collaborate cross-functionally with a diverse design-make-test team across Abiologics and have the opportunity to impact platform and company growth.

Requirements

PhD in molecular or cell biology or related discipline with up to 2 years relevant experience; industry experience is preferred
Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines
Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays; experience with cellular/high content imaging and image analysis a plus (e.g., Incucyte, Phenix)
Experienced with primary cell culture and characterization, including tissue dissociation
Experienced in assay development and testing in model systems and human with good understanding of analytical and pre-analytical methods and solutions
Demonstrated ability to independently design, develop and optimize diverse cell-based functional assays (e.g., intracellular signaling) and interpret complex results
Industry level experience with best practices related to data records creation and maintenance and workflow integrity
Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality

Nice To Haves

Strong proficiency in renal disease biology and preclinical kidney models is highly desirable
In vivo pharmacology experience would be a plus
Proficiency in laboratory automation and semi-automated screening workflows is a plus

Responsibilities

Design and execute cell-based and biochemical assays to assess SynteinTM activity, target engagement, and mechanism of action to drive discovery programs
With guidance from manager, conceptualize and develop novel assays for diverse target classes and disease areas
Collaborate with the Pharmacology team on biochemistry and biophysics projects and provide cell biology expertise
Contribute to in vivo and ex vivo pharmacology activities to progress projects and the platform
Collaborate cross-functionally to enable novel methods, assays and screening workflows, including optimization of assays for incorporation into screening funnels and cross-training of colleagues on methods
Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry & Screening teams to drive design-make-test cycles
Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings