Principal Scientist, Computational-Immunology Discovery
About The Position
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. We are searching for the best talent for a Principal Scientist, Computational-Immunology Discovery, to be in Spring House, PA, La Jolla, CA or Cambridge, MA. This role is on the Immune Pathway Discovery (IPD) team which is part of Immunology Discovery in the Immunology Therapeutic Area. IPD is responsible for identifying the next wave of transformational therapeutic pathways and applying human ‘omics data to advance our Discovery portfolio. We analyze and interpret high-dimensional molecular ‘omics data to identify new therapeutic pathways, build disease rationales, and identify patient stratification approaches. IPD supports Discovery projects from inception, through preclinical testing, and up to the transition to clinical trials. We partner closely with biologists to formulate questions, interpret results, and apply the insights we generate to influence the strategic direction of the program. This is an individual contributor role focused on supporting key projects and initiatives with computational analysis. The successful candidate will have a strong technical background in bioinformatics and established track record of using bioinformatics to drive business impact. Due to the interdisciplinary nature of this role, strong technical, collaboration, communication, and time management skills are critical.
Requirements
- PhD in a field relevant to bioinformatics including, but not limited to, Computational Biology, Immunology, Biostatistics, or Computer Science.
- 4+ years work experience using computational biology to discover biological insights from molecular data in immunology or an immunology-related field.
- Deep technical expertise analyzing ‘omics data, including bulk and single cell RNA-seq.
- Fluent in R and/or Python.
- A proven ability to communicate and collaborate across disciplines.
- Exceptional scientific rigor and attention to detail.
- Agentic AI and AI-assisted coding experience in an industry setting, or a strong motivation to learn.
Nice To Haves
- Cloud computing experience is a plus.
- Background in inflammatory diseases, wet lab experience is a plus.
- Motivation to shape the technical direction of Immune Pathway Discovery by piloting new approaches and demonstrating their potential impact.
- Expertise in machine learning, spatial transcriptomics, or network biology.
- Ability to build and leverage a strong scientific network to drive portfolio impact.
Responsibilities
- Independently build, align, and execute technical plans to achieve objectives across multiple programs.
- Timely delivery of hands-on data analysis, visualization, and interpretation for Discovery portfolio decision-making.
- Substantially impact Discovery programs through direct technical execution and indirect contribution as a member of Discovery project teams.
- Collaborate with cross-functional teams to drive computational insights for Discovery programs.
Benefits
- medical
- dental
- vision
- life insurance
- short- and long-term disability
- business accident insurance
- group legal insurance
- consolidated retirement plan (pension)
- savings plan (401(k))
- long-term incentive program
- Vacation – up to 120 hours per calendar year
- Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year
- Holiday pay, including Floating Holidays – up to 13 days per calendar year
- Work, Personal and Family Time - up to 40 hours per calendar year
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
