Scientist I/II, Gene Editing System Protein Engineering and Optimization

We are seeking a creative and collaborative Scientist to join our Discovery division in Emeryville, California. As a Scientist, you will contribute to the optimization of protein sequences and constructs for gene editing systems, with a focus on CRISPR-associated transposases (CASTs) and other systems. Your responsibilities will include generating and screening libraries, constructing protein fusions, and selecting improved variants. You will collaborate with interdisciplinary teams and have the opportunity to make a lasting impact in building an industry-leading gene editing tool kit.

• Generate and screen variant libraries of metagenomics-derived proteins to identify high-performing systems
• Optimize complex systems through structure-driven rational protein engineering
• Collaborate with the mammalian cell translation team to design and test protein fusion constructs for increased cell editing efficiency and specificity
• Contribute to the screening for novel enzymes and constructs
• Identify and implement new tools and methods utilizing expertise in protein engineering
• Communicate results and findings to wider teams and coordinate discovery projects with Novel Systems, Mammalian Cell Translation, Biochemistry/Biophysical, and other teams

• Ph.D. in Protein Engineering, Biochemistry, or a related discipline and relevant applied protein engineering research experience
• Expertise and knowledge of up-to-date methods and tools for optimizing proteins based on structure/function relationships
• Experience in high-throughput plasmid construction and expressing proteins in mammalian cells
• Experience designing and performing high-throughput selection screens in mammalian cells
• Effective oral and written communication, prioritization, and organizational skills
• The ability to quickly learn and adapt to new projects and tools
• A highly collaborative and solutions-oriented outlook, and thrive in a fast-moving startup environment

• Competitive compensation including a market-benchmarked salary
• Annual target bonus
• Equity in an early-stage startup
• Comprehensive benefits plan
• 401(k) matching
• Retirement safe harbor plan
• Catered lunches and endless snacks
• Strong commitment to work/life balance
• Weekly employee happy hour and events
• Open, collegial, and friendly work environment
• Opportunities for long-term career development
• Equal-opportunity employer that values diversity and inclusion
• Authorization to work in the United States