Scientist II

Roche • South San Francisco, CA

4d • $85,500 - $158,700 • Onsite

About The Position

As a Scientist II on the Small Molecule Biomarkers (Metabolomics & Lipidomics) team within the Drug Metabolism and Pharmacokinetics (DMPK) department at Genentech Research and Early Development (gRED), you will support drug discovery by executing high-throughput mass spectrometry workflows and using modern tools, including Generative AI, to generate biological insights. The position is based onsite in South San Francisco.

The role involves performing LC-MS biomarker workflows, preparing samples with liquid-handling automation, processing and analyzing mass spectrometry data, applying bioanalytical quality controls, and documenting experiments and study reports. You will also support routine laboratory operations, including instrument maintenance, inventory management, and compliance with laboratory safety and quality standards.

Requirements

• Bachelor’s or Master’s degree in biological, chemical, pharmaceutical sciences, or a related field.
• At least 5 years of direct biotechnology or pharmaceutical industry experience with a Bachelor’s degree, or at least 3 years with a Master’s degree.
• Experience executing LC-MS assays for endogenous small-molecule metabolites or lipids.
• Experience with sample preparation techniques such as protein precipitation, liquid-liquid extraction, or solid-phase extraction.
• Practical experience operating and troubleshooting modern LC-MS platforms, such as UHPLC, triple quadrupole, and high-resolution mass spectrometers.
• Experience using analytical data-processing software.
• A solid foundation in biochemistry and cellular metabolism.
• Excellent communication skills and a track record of effective work in multidisciplinary project teams.

Nice To Haves

• Hands-on experience or strong aptitude using Generative AI tools for coding.

Responsibilities

• Perform onsite laboratory-based LC-MS workflows to acquire biomarker data supporting target biology evaluation, drug discovery, and development.
• Use liquid-handling automation to perform sample preparation, including protein precipitation, liquid-liquid extraction, solid-phase extraction, and chemical derivatization.
• Prepare and execute global and targeted metabolomics and lipidomics protocols using biofluids, tissues, and cells.
• Process mass spectrometry data and perform statistical analysis using in-house AI/ML workflows and commercial software tools.
• Apply rigorous bioanalytical quality control using common industry practices and critical analytical reasoning.
• Organize and document accurate experimental records under the guidance of lead scientists, supporting timely delivery of data and study reports.
• Support routine laboratory operations, including instrument maintenance, consumable and chemical management, and compliance with laboratory safety and quality standards.

Benefits

• A discretionary annual bonus may be available based on individual and Company performance.
• The position qualifies for the benefits described at the company-provided benefits link.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level