Scientist II, Translational Science

ModeX Therapeutics • Weston, MA

1h

About The Position

ModeX Therapeutics is seeking a highly skilled and motivated Scientist II to support the development and execution of biomarker strategies across early-stage clinical programs. The role contributes to designing, implementing, and interpreting biomarker studies that inform mechanism of action, patient selection, pharmacodynamic activity, and clinical development decisions. The successful candidate will analyze biomarker data from clinical studies, manage biomarker datasets, and conduct translational in vitro studies supporting biomarker discovery and method development. The position helps generate translational insights that advance therapeutic programs from early clinical development through proof-of-concept and support data-driven decisions.

Requirements

• PhD in Immunology or a related field.
• 2–5+ years of highly relevant work experience in Immunology, preferably Immuno-Oncology and T cell biology, with a good track record in industry or academia.
• Hands-on experience in immune cell assays and multi-parameter flow cytometry.
• Ability to interpret and communicate complex biological datasets.
• Proficiency with data analysis and visualization tools, such as GraphPad Prism or R.
• Good written and oral communication and organizational skills, with experience in data generation and analysis.
• Strong learning ability, troubleshooting, and problem-solving skills.
• Ability to adapt to a fast-paced working environment and work effectively both in a team and individually.

Nice To Haves

• Experience supporting biomarker activities in clinical development.
• Experience with antibody-based therapeutics.

Responsibilities

• Support the development and execution of clinical biomarker plans for clinical studies.
• Contribute to the selection, validation, and implementation of biomarker assays, including flow cytometry, immunophenotyping, cytokine analyses, soluble biomarkers, genomics, transcriptomics, and tissue-based assays.
• Monitor biomarker sample quality, assay performance, and data delivery timelines.
• Manage activities and deliverables of external laboratories, CROs, and academic collaborators.
• Review, analyze, interpret, and visualize biomarker data to support study objectives and decision-making.
• Integrate biomarker, clinical, pharmacokinetic (PK), and safety data to generate biological insights.
• Prepare biomarker data summaries, reports, presentations, and study team updates.
• Maintain awareness of emerging biomarker technologies, therapeutic area trends, and translational research advances.
• Perform translational science studies to support IND-enabling studies, accelerate biomarker discovery, and advance preclinical and clinical programs.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree