Associate Scientist, Translational Biology

Septerna•South San Francisco, CA

3h•$100,000 - $110,000•Onsite

About The Position

Septerna is a biotechnology company developing GPCR-targeted small-molecule medicines through its Native Complex Platform™. The Associate Scientist will support advancement of the company’s drug discovery pipeline by developing and conducting in vivo, ex vivo, and in vitro studies in Translational Sciences. The role includes independently and collaboratively designing and executing experiments in preclinical models to understand in vivo pharmacology, establish PK/PD relationships, and inform the efficacy and mechanism of action of therapeutic candidates. The scientist will generate and analyze functional data to help rank candidates for preclinical development and may contribute to biomarker discovery efforts. The position is based in South San Francisco, California, and is expected to be primarily laboratory-based with some desk work. The successful candidate will work with multidisciplinary project teams and contribute to preclinical research that helps position therapies for clinical development. Title is commensurate with experience.

Requirements

BSc or MSc in Pharmacology, Toxicology, or a related biological science.
At least 4 years of direct, full-time hands-on experience with in vivo studies or disease models; 2 years is accepted with an MSc.
Hands-on experience working with rodent models, including mice and rats, multiple administration routes (such as oral, subcutaneous, intraperitoneal, intravenous, and intramuscular), and sample collection (such as submandibular or tail-vein bleeding and cardiac puncture).
Experience working with other scientists to analyze, interpret, and present data.
Ability to collaborate on writing protocols and troubleshooting biological experiments.
Detail-oriented and organized, with strong interpersonal skills and the ability to communicate clearly, engage proactively, and collaborate with colleagues.

Responsibilities

Design and execute in vivo pharmacology studies to understand therapeutic mechanisms in relevant disease models.
Generate, analyze, document, and help interpret data to establish functional PK/PD relationships.
Collaborate to determine drug candidates’ mechanisms of action in in vivo, in vitro, and ex vivo models.
Participate in multiple project teams and present results in laboratory, team, and department meetings.
Conduct literature searches and interpret papers to help design and troubleshoot in vivo and in vitro experiments.
Help author in vivo pharmacology study designs, protocols, and reports to support regulatory filings.
Follow company policies and practices and maintain accurate records and notebooks.