Scientist II/Sr. Scientist I, Chemical Biology (Must Have Intact Mass Spectrometry Experience)
About The Position
Antares Therapeutics is seeking a motivated and detail-oriented Scientist II/ Sr Scientist I to join our Chemical Biology team. As a member of the team, you will be responsible for designing and executing proteomic screens to identify and validate novel therapeutic targets, elucidate mechanisms of inhibition, and enable biophysical small-molecule characterization through cycles of hit identification and SAR advancement. Achieving these objectives will involve the application of innovative chemoproteomic methodologies and the utilization of advanced HPLC and mass spectroscopy (MS) instrumentation. This position offers a unique opportunity to work in a collaborative, fast-paced environment at the intersection of chemistry and biology.
Requirements
- PhD. in Chemical Biology, Analytical Chemistry, Biochemistry, Proteomics, or a related discipline with 2–6 years of relevant industry and/or postdoctoral experience
- Proficiency in operating and maintaining mass spectrometry and liquid chromatography instrumentation is required
- Previous experience with MS-based proteomic methods to study protein/peptide modification, protein turnover, and/or targets using enrichment methods is required
- Ability to perform routine laboratory tasks requiring manual dexterity, including pipetting, sample preparation, and operation of analytical instrumentation
Nice To Haves
- Experience in small molecule drug mechanisms of action (e.g., covalent ligands, molecular glues, PROTACs, etc.) is desirable
- Knowledge/experience with activity-based protein profiling (ABPP) is desirable
- Familiarity with Proteome Discoverer, Skyline, DIA-NN, Spectronaut, MaxQuant, or related proteomics software is desirable
- Programming experience and data analysis (g., Python or R) for statistical analysis, visualization, and interpretation of large biological datasets is desirable
Responsibilities
- Serve as the chemical biology functional lead on programs, reporting and presenting discovery evidence for multiple small-molecule programs
- Design and execution of MS-based chemical biology experiments supporting target hit finding, compound profile optimization, and mechanism-of-action studies
- Analyze experimental data, interpret results, and present findings at internal meetings. Maintain accurate and detailed laboratory records as well as up-to-date electronic notebooks
- Design and execute quantitative proteomics experiments using data-independent acquisition (DIA) or targeted workflows
- Contribute to the development of new proteomic workflows and the evaluation of emerging chemical biology strategies
- Help maintain Orbitrap-based mass spectrometer and HPLC instrumentation
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
