Scientist II, Bioanalytical

Novo Nordisk • Lexington, MA

6h • Onsite

About The Position

The Scientist II, Bioanalytical (LCMS) will be responsible for the design, development, and execution of novel quantitative liquid chromatographic and mass spectroscopic (LCMS) assays to support in-vivo and in-vitro pharmacology studies. This role involves working with diverse modalities such as proteins, peptides, small molecules, and oligonucleotides, contributing to the understanding of PK/PD and biomarkers related to efficacy and toxicity. The position requires advancing scientific ideas through experimental design and execution, ensuring data integrity and reproducibility, and communicating results to various project teams. Collaboration with internal teams (Chemical Biology, In-vivo Pharmacology) and global colleagues, as well as external CROs, is essential. The role demands hands-on laboratory work, including method building, data interpretation, and instrument maintenance. The Scientist II will act as an individual contributor, bringing subject matter and technical expertise to project teams and contributing to the Bioanalysis Department's knowledge base.

Requirements

• Bachelor's Degree required.
• BS/BA Degree with 8+ years’ relevant experience required, or a master’s degree with 6+ years’ relevant experience, or a Doctoral/PhD degree with 2+ years of relevant experience required.
• Demonstrated subject matter expertise in LCMS assay concepts, techniques, and technology platforms.
• Experienced in analyte extraction and sample preparation from complex biological matrixes for injection onto LCMS systems (e.g., protein precipitation, SPE, LLE, IP-MS).
• Work with diverse modalities (e.g., antibodies, proteins, peptides, small molecules, oligonucleotides).
• Solid understanding of PK/PD modelling concepts as they relate to preclinical animal models and analytical methods.
• Practical skills in one or more LCMS systems, methods, and associated software (e.g., Thermo Scientific, Sciex, Waters/Acquity, triple quad, HRMS, column chromatography, Xcalibur, Chromeleon, BioPharma Finder, Proteome Discoverer, Sciex OS).
• Experience working in a bioanalytical laboratory.
• Demonstrates excellent verbal and written communication skills.
• Demonstrates outstanding project management knowledge, as well as organizational and time management skills.

Nice To Haves

• Lab automation and liquid handling instrumentation.
• Experience using WinNonlin.
• Experience working at or with CROs.
• Knowledge of GLP bioanalytical principles.

Responsibilities

• Design, develop, and execute novel quantitative LCMS assays.
• Support in-vivo and in-vitro pharmacology studies.
• Work with diverse modalities including proteins, peptides, small molecules, and oligonucleotides.
• Contribute to understanding PK/PD and biomarkers of interest.
• Advance scientific ideas through experimental design and execution.
• Ensure data integrity and reproducibility.
• Communicate results to diverse project teams.
• Collaborate with scientists within Chemical Biology, In-vivo Pharmacology, and other teams.
• Collaborate with global organization and external CROs.
• Bring subject and technical matter expertise to project teams.
• Perform critical and detailed analytical evaluations of data.
• Effectively communicate data evaluations.
• Perform hands-on laboratory work: building analytical methods, summarizing and interpreting experimental results, and maintaining instrumentation and reagents.
• Provide bioanalytical expertise in LCMS systems and its application in qualitative and quantitative analysis, PK assays, Met ID, and biomarker exploration.
• Serve as bioanalytical representative to project teams.
• Design and perform LCMS analytical methods that are fit for purpose and produce quality, value-adding data.
• Work with CROs as needed, including contract establishment, communication of clear statements of work, and critical oversight of data.
• Critically evaluate experimental results and analyze data using appropriate mathematical modeling and software.
• Create clear written and oral summaries for presentation to project teams.
• Independently draw conclusions from experiments and provide input on future directions.
• Effectively communicate experimental results within and outside the functional area.
• Guide project teams and other focus groups with subject matter expertise and interpretation.
• Present and report to project governance bodies and other stakeholders.
• Elucidate with project team how to best interrogate endpoints of interest in alignment with study goals.
• Contribute to the department team’s knowledge by providing updates on relevant scientific literature and technology.
• Maintain and troubleshoot relevant lab instruments.
• Contribute to effective management of consumables, reagents, sample inventories, and other shared resources.

Benefits

• Company bonus based on individual and company performance.
• Long-term incentive compensation.
• Company vehicles (depending on position's level or other company factors).
• Medical coverage.
• Dental coverage.
• Vision coverage.
• Life insurance.
• Disability insurance.
• 401(k) savings plan.
• Flexible spending accounts.
• Employee assistance program.
• Tuition reimbursement program.
• Voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance.
• Time off pursuant to its sick time policy.
• Flex-able vacation policy.
• Parental leave policy.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level