Scientist I

AbbVie•Waltham, MA

7h•$75,000 - $142,500•Onsite

About The Position

Investigate, identify, develop, and optimize methods and techniques that generate reliable and reproducible data in a timely manner. Read and adapt scientific literature to complete assignments and demonstrate broad, versatile technical expertise within the discipline. The role develops and optimizes analytical methods using separation-based techniques to characterize biopharmaceutical products, interprets experimental results, troubleshoots analytical issues, and contributes primarily through laboratory and/or pilot plant activities. The candidate is expected to work onsite at AbbVie’s Worcester and Waltham sites as needed.

Requirements

Bachelor’s degree or equivalent education with typically five years of experience, or a master’s degree or equivalent education with typically two years of experience.
Theoretical and practical knowledge sufficient to carry out the job functions.

Nice To Haves

Strong understanding of protein biochemistry and analytical method development principles.
Experience developing and optimizing charge-variant analysis methods, including icIEF and CEX, and transferring methods to a QC environment.
Proficiency operating and troubleshooting analytical instrumentation such as Agilent and Waters HPLC systems, Maurice, and PA800 systems.
Experience qualifying and validating analytical methods in accordance with ICH, FDA, and USP guidelines, with methods suitable for late-phase development and regulatory submissions.
Experience using automation to standardize high-throughput workflows.
Familiarity with statistical tools for data analysis, Empower, and regulatory guidelines.
Experience collaborating with process development, quality control, and regulatory affairs teams to align analytical strategies with project timelines and goals.
Ability to provide technical guidance and mentorship to junior scientists and laboratory staff.

Responsibilities

Independently design, develop, and optimize robust analytical methods using HPLC, icIEF, and CE-SDS to characterize biopharmaceutical products.
Implement and innovate experimental protocols and techniques.
Maintain a strong understanding of project goals and proficiency in assigned projects and the overall program.
Interpret results from multistage experiments, identify significant deviations, and propose, design, and conduct relevant follow-up experiments.
Apply relevant scientific literature and theoretical frameworks to solve discipline-related problems in a timely manner.
Perform routine and complex tasks competently and independently, generating reliable and consistent results.
Troubleshoot complex analytical issues and implement solutions to improve method performance and efficiency.
Contribute to projects primarily through laboratory and/or pilot plant activities.
Comply with applicable Corporate and Divisional policies and procedures.
Follow corporate standards for conduct, safety, material handling, controlled drugs and radioactive compounds, GxP compliance, and animal care where applicable.