Scientist - HTS Oligo Synthesis

EMD Serono Research & Development Institute • Billerica, MA

5d

About The Position

EMD Serono in Billerica, MA is seeking a Scientist – HTS Oligo Synthesis to add to their Oligonucleotide Therapeutics Group (DDTech).

Requirements

• PhD in Chemical Engineering, Chemistry, Biochemistry or other Science discipline
• Master’s degree in Chemical Engineering, Chemistry, Biochemistry or other Science or Engineering discipline with 3+ years of experience in oligonucleotide field
• Bachelor’s degree in Chemical Engineering, Chemistry, Biochemistry or other Science or Engineering discipline with 5+ years of experience in oligonucleotide field

Nice To Haves

• Good understanding of Oligonucleotide chemistry
• Experience with a wide range of Oligo purification/analytical techniques, especially HPLC and/or HPLC-MS
• Experience performing desalting by using gel filtration or membrane filtration techniques
• High degree of flexibility and motivation in a fast-paced work environment

Responsibilities

• Synthesis of oligonucleotides, deprotection, purification, desalting and lyophilization of oligonucleotides
• Operate Expedite/ABI/Mermade synthesizers and HPLC systems
• Prepare oligonucleotide synthesis reagents and synthesize, process, and purify ASO/siRNA using automated instruments by anion-exchange and reverse-phase HPLC systems
• Desalt, concentrate, and lyophilize final Oligo’s material using appropriate instrumentation or techniques
• Maintain a well-documented laboratory notebook and follow the safe laboratory practices
• Operate and troubleshoot available instruments including HPLC and MS
• Maintain an electronic laboratory notebook and miscellaneous documentation and maintain reagent inventory

Benefits

• health insurance
• paid time off (PTO)
• retirement contributions

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree