Senior Scientist - HTS Oligo Synthesis

EMD Serono Research & Development Institute•Billerica, MA

12d

About The Position

EMD Serono in Billerica, MA is seeking a Senior Scientist – HTS Oligo Synthesis to add to their Oligonucleotide Therapeutics Group (DDTech). Responsibilities: Support pre-clinical oligonucleotide high-throughput synthesis capabilities of ASOs, siRNA, SSO, with routine and novel next generation amidite chemistries Solid phase synthesis of oligonucleotides at various scales, chemical modifications of nucleosides and backbones Operate Expedite/ABI/Mermade synthesizers using Phosphoramidite chemistry Maintain a deep understanding of oligonucleotide and precursor synthesis, modification, purification, and conjugation mechanisms Perform analytical methods and quality standards in oligonucleotide drug development Purification of oligonucleotides by anion-exchange and reverse-phase HPLC systems Work as part of a team and present findings during team meetings Maintain a well-documented laboratory notebook and follow the safe laboratory practices Multi-task across several projects and manage time effectively to achieve results Who You Are Minimum Qualifications: PhD in Chemistry, Biochemistry, Chemical Engineering, or other Science field 5+ years of direct experience in oligonucleotide chemistry Preferred Qualifications: Strong knowledge of Oligonucleotide Synthesis, Deprotection and Purification techniques Knowledge and background in bioconjugation chemistry including antibody-drug conjugates and related linkers Experience in conjugation/bioconjugation chemistry. Solid-phase synthesis techniques with oligonucleotides or peptides Expertise in chromatography purification techniques and troubleshooting Strong laboratory skills and experience with analytical instrumentation such as NMR, HPLC, LC-MS, etc. with the ability to analyze, interpret, and clearly present data

Requirements

PhD in Chemistry, Biochemistry, Chemical Engineering, or other Science field
5+ years of direct experience in oligonucleotide chemistry

Nice To Haves

Strong knowledge of Oligonucleotide Synthesis, Deprotection and Purification techniques
Knowledge and background in bioconjugation chemistry including antibody-drug conjugates and related linkers
Experience in conjugation/bioconjugation chemistry. Solid-phase synthesis techniques with oligonucleotides or peptides
Expertise in chromatography purification techniques and troubleshooting
Strong laboratory skills and experience with analytical instrumentation such as NMR, HPLC, LC-MS, etc. with the ability to analyze, interpret, and clearly present data

Responsibilities

Support pre-clinical oligonucleotide high-throughput synthesis capabilities of ASOs, siRNA, SSO, with routine and novel next generation amidite chemistries
Solid phase synthesis of oligonucleotides at various scales, chemical modifications of nucleosides and backbones
Operate Expedite/ABI/Mermade synthesizers using Phosphoramidite chemistry
Maintain a deep understanding of oligonucleotide and precursor synthesis, modification, purification, and conjugation mechanisms
Perform analytical methods and quality standards in oligonucleotide drug development
Purification of oligonucleotides by anion-exchange and reverse-phase HPLC systems
Work as part of a team and present findings during team meetings
Maintain a well-documented laboratory notebook and follow the safe laboratory practices
Multi-task across several projects and manage time effectively to achieve results