Senior Scientist - HTS Oligo Synthesis

Merck•Billerica, MA

12d

About The Position

Work Your Magic with us! Start your next chapter and join EMD Serono. Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us. United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe. This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US. Your Role: EMD Serono in Billerica, MA is seeking a Senior Scientist – HTS Oligo Synthesis to add to their Oligonucleotide Therapeutics Group (DDTech).

Requirements

PhD in Chemistry, Biochemistry, Chemical Engineering, or other Science field
5+ years of direct experience in oligonucleotide chemistry

Nice To Haves

Strong knowledge of Oligonucleotide Synthesis, Deprotection and Purification techniques
Knowledge and background in bioconjugation chemistry including antibody-drug conjugates and related linkers
Experience in conjugation/bioconjugation chemistry.
Solid-phase synthesis techniques with oligonucleotides or peptides
Expertise in chromatography purification techniques and troubleshooting
Strong laboratory skills and experience with analytical instrumentation such as NMR, HPLC, LC-MS, etc. with the ability to analyze, interpret, and clearly present data

Responsibilities

Support pre-clinical oligonucleotide high-throughput synthesis capabilities of ASOs, siRNA, SSO, with routine and novel next generation amidite chemistries
Solid phase synthesis of oligonucleotides at various scales, chemical modifications of nucleosides and backbones
Operate Expedite/ABI/Mermade synthesizers using Phosphoramidite chemistry
Maintain a deep understanding of oligonucleotide and precursor synthesis, modification, purification, and conjugation mechanisms
Perform analytical methods and quality standards in oligonucleotide drug development
Purification of oligonucleotides by anion-exchange and reverse-phase HPLC systems
Work as part of a team and present findings during team meetings
Maintain a well-documented laboratory notebook and follow the safe laboratory practices
Multi-task across several projects and manage time effectively to achieve results