Senior Scientist - Oligo Bioinformatics

The businesses of Merck KGaA, Darmstadt, Germany•Billerica, MA

About The Position

Work Your Magic with us! Start your next chapter and join EMD Serono. Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us. United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe. This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US. Your Role: EMD Serono in Billerica, MA is seeking a Senior Scientist – Oligo Bioinformatics to add to their Oligonucleotide Therapeutics Group (DDTech). Discovery and development of oligonucleotide therapeutics Who You Are:

Requirements

PhD in Chemistry, Chemical Engineering, Computer Science or other Science field with 3+ years of direct experience in siRNA/ASO/SSO

Nice To Haves

Experience with common human genetics resources and techniques
Deployment of interactive applications from scripting languages like R and Python (Shiny and streamlit)
Experience with relational databases; hands on experience with MySQL
Experience in common NGS analyses task such mapping reads, quantification of gene expression, and/or variant calling
Experience with common bioinformatics tools like Samtools, GATK, Bowtie, HISAT2, BLAST, htseq-count, DESeq, Salmon, STAR, or Subread
Knowledge of Illumina sequencing data analysis is necessary and experience with PacBio and/or Nanopore sequencing
Familiarity with UNIX computing environment and proficiency in either Python or R scripting
Experience with docker and Nextflow pipeline
Ability to communicate finding of NGS data to a general scientific audience in both oral and written forms

Responsibilities

Develop pipelines that determine mapping coordinates and homology of oligonucleotides to genomes and transcriptomes
Design and build pipelines that process and analyze related data, store summary results and integrate with the corporate ELN
Develop pipelines that determine mapping coordinates and homology of oligonucleotides to genomes and transcriptomes
Develop, deploy, manage, and run applications using Docker containers