Senior Scientist - HTS Oligo Synthesis
About The Position
EMD Serono in Billerica, MA is seeking a Senior Scientist – HTS Oligo Synthesis to add to their Oligonucleotide Therapeutics Group (DDTech). Responsibilities: Support pre-clinical oligonucleotide high-throughput synthesis capabilities of ASOs, siRNA, SSO, with routine and novel next generation amidite chemistries Solid phase synthesis of oligonucleotides at various scales, chemical modifications of nucleosides and backbones Operate Expedite/ABI/Mermade synthesizers using Phosphoramidite chemistry Maintain a deep understanding of oligonucleotide and precursor synthesis, modification, purification, and conjugation mechanisms Perform analytical methods and quality standards in oligonucleotide drug development Purification of oligonucleotides by anion-exchange and reverse-phase HPLC systems Work as part of a team and present findings during team meetings Maintain a well-documented laboratory notebook and follow the safe laboratory practices Multi-task across several projects and manage time effectively to achieve results
Requirements
- PhD in Chemistry, Biochemistry, Chemical Engineering, or other Science field
- 5+ years of direct experience in oligonucleotide chemistry
Nice To Haves
- Strong knowledge of Oligonucleotide Synthesis, Deprotection and Purification techniques
- Knowledge and background in bioconjugation chemistry including antibody-drug conjugates and related linkers
- Experience in conjugation/bioconjugation chemistry. Solid-phase synthesis techniques with oligonucleotides or peptides
- Expertise in chromatography purification techniques and troubleshooting
- Strong laboratory skills and experience with analytical instrumentation such as NMR, HPLC, LC-MS, etc. with the ability to analyze, interpret, and clearly present data
Responsibilities
- Support pre-clinical oligonucleotide high-throughput synthesis capabilities of ASOs, siRNA, SSO, with routine and novel next generation amidite chemistries
- Solid phase synthesis of oligonucleotides at various scales, chemical modifications of nucleosides and backbones
- Operate Expedite/ABI/Mermade synthesizers using Phosphoramidite chemistry
- Maintain a deep understanding of oligonucleotide and precursor synthesis, modification, purification, and conjugation mechanisms
- Perform analytical methods and quality standards in oligonucleotide drug development
- Purification of oligonucleotides by anion-exchange and reverse-phase HPLC systems
- Work as part of a team and present findings during team meetings
- Maintain a well-documented laboratory notebook and follow the safe laboratory practices
- Multi-task across several projects and manage time effectively to achieve results
Benefits
- health insurance
- paid time off (PTO)
- retirement contributions
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
