Scientist - HTS Oligo Synthesis
About The Position
EMD Serono in Billerica, MA is seeking a Scientist – HTS Oligo Synthesis to add to their Oligonucleotide Therapeutics Group (DDTech). Responsibilities: Synthesis of oligonucleotides, deprotection, purification, desalting and lyophilization of oligonucleotides Operate Expedite/ABI/Mermade synthesizers and HPLC systems Prepare oligonucleotide synthesis reagents and synthesize, process, and purify ASO/siRNA using automated instruments by anion-exchange and reverse-phase HPLC systems Desalt, concentrate, and lyophilize final Oligo’s material using appropriate instrumentation or techniques Maintain a well-documented laboratory notebook and follow the safe laboratory practices Operate and troubleshoot available instruments including HPLC and MS Maintain an electronic laboratory notebook and miscellaneous documentation and maintain reagent inventory
Requirements
- PhD in Chemical Engineering, Chemistry, Biochemistry or other Science discipline
- Master’s degree in Chemical Engineering, Chemistry, Biochemistry or other Science or Engineering discipline with 3+ years of experience in oligonucleotide field
- Bachelor’s degree in Chemical Engineering, Chemistry, Biochemistry or other Science or Engineering discipline with 5+ years of experience in oligonucleotide field
Nice To Haves
- Good understanding of Oligonucleotide chemistry
- Experience with a wide range of Oligo purification/analytical techniques, especially HPLC and/or HPLC-MS
- Experience performing desalting by using gel filtration or membrane filtration techniques
- High degree of flexibility and motivation in a fast-paced work environment
Responsibilities
- Synthesis of oligonucleotides, deprotection, purification, desalting and lyophilization of oligonucleotides
- Operate Expedite/ABI/Mermade synthesizers and HPLC systems
- Prepare oligonucleotide synthesis reagents and synthesize, process, and purify ASO/siRNA using automated instruments by anion-exchange and reverse-phase HPLC systems
- Desalt, concentrate, and lyophilize final Oligo’s material using appropriate instrumentation or techniques
- Maintain a well-documented laboratory notebook and follow the safe laboratory practices
- Operate and troubleshoot available instruments including HPLC and MS
- Maintain an electronic laboratory notebook and miscellaneous documentation and maintain reagent inventory
Benefits
- health insurance
- paid time off (PTO)
- retirement contributions
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
