Scientist (Genomics / Gene Editing & Bioinformatics) - Wlodarski Lab

St. Jude Children's Research Hospital•Memphis, TN

13d•$86,320 - $154,960

About The Position

The Scientist independently designs, performs, and coordinates a broad range of advanced laboratory and computational research activities supporting cutting-edge genomics programs focused on hematologic disorders and cancer predisposition. Research efforts span multi-omics studies (genomics, transcriptomics, epigenomics) and genome editing. Particular emphasis is on characterizing novel genes and clonal lesions that drive clonal evolution, and on developing therapeutic base-editing strategies. The Scientist develops and executes experimental strategies integrating both wet lab techniques and bioinformatics analyses, contributing to projects that span discovery through data interpretation. This role requires the ability to analyze, interpret, and present complex biological datasets, while actively contributing to experimental design, protocol development, and scientific reporting. The ideal candidate brings primary expertise in either wet lab biology or computational biology, along with working knowledge of the complementary discipline (e.g., wet lab scientists with bioinformatics exposure, or computational scientists with hands-on laboratory experience), enabling effective collaboration across interdisciplinary teams. About the lab: This position is part of the Marcin Wlodarki Lab at St. Jude Children’s Research Hospital, which focuses on advancing our understanding of genetic and genomic drivers of hematologic disorders and cancer predisposition. The lab integrates translational research, functional genomics, and computational approaches to uncover disease mechanisms and improve patient outcomes. The lab PI directs the institution's clinical Bone Marrow Failure (BMF) Program and co-leads the PARADIGM gene editing program, creating a direct bridge between patient care and discovery science.

Requirements

Bachelor's degree in relevant scientific area is required
Eight (8) years of relevant work experience is required
Six (6) years of relevant work experience is required with a Master's degree
Three (3) years of relevant work experience is required with a PhD

Nice To Haves

Strong experience in genetics/genomics and gene editing technologies (CRISPR-Cas9, base editing, prime editing)
Proven experience in bioinformatics or computational biology, particularly genomic data analysis
A combination of wet lab and computational expertise
Demonstrated track record of scientific contributions (e.g., publications, project leadership, or impactful research outcomes)

Responsibilities

Design, coordinate, and execute research projects involving genetics/genomics, including gene editing technologies (e.g., CRISPR-Cas9 and base editing) and downstream analysis
Perform laboratory experiments and apply appropriate techniques; evaluate methodologies and recommend alternative approaches or tools as needed
Conduct bioinformatics and computational analyses of genomic datasets, including processing, organization, interpretation, and visualization of data
Contribute to the development, optimization, and implementation of new laboratory and computational protocols
Identify and extract relevant experimental data; ensure accuracy, quality, and integrity of datasets and analyses
Summarize and communicate research findings through reports, presentations, and contributions to manuscripts/publications
Support laboratory operations, including equipment maintenance, calibration and troubleshooting
Maintain inventory and ensure proper functioning of laboratory and computational resources
Train and mentor staff or junior researchers in laboratory techniques, data analysis methods, and best practices
Maintain regular and predictable attendance
Perform other related duties as assigned to support departmental and institutional goals