Scientist – Disease Biology Discovery Research

Amgen•South San Francisco, CA

1d•$123,053 - $166,483

About The Position

This permanent role is within Amgen Research’s Cardiometabolic Disorders Department in South San Francisco. The scientist will develop a deep understanding of disease biology, identify novel drug targets in non-oncology areas, and contribute to advancing the preclinical pipeline. The team investigates a diverse range of indications, including cardiac, cardiovascular, fibrotic, and renal diseases. The role calls for strong molecular and cell biology laboratory skills, scientific curiosity, and interpersonal and communication skills to work effectively in a collaborative environment. It offers opportunities for advancement and career development.

Requirements

Doctorate degree (PhD), or a master’s degree and 2 years of Molecular and Cell Biology experience, or a bachelor’s degree and 4 years of Molecular and Cell Biology experience.
Strong molecular and cell biology laboratory skills.
Scientific curiosity and strong interpersonal and communication skills.
Extensive experience with cell-based, molecular, and biochemical techniques, including RNA isolation/qPCR, protein immunoprecipitation, immunoblotting, ELISA, flow cytometry, and cell imaging and image processing.
Extensive experience performing in vitro and cellular assays to investigate gene function or therapeutic molecule mechanisms of action, demonstrated by high-impact publications.
Strong interpersonal and organizational skills, accuracy, commitment to record keeping, and attention to detail.
Demonstrated experience analyzing and interpreting complex datasets.

Nice To Haves

Expertise with cell line engineering technologies, including CRISPR and virus-based stable cell line generation.
Expertise with human iPSCs, especially iPSC-derived cardiomyocytes.

Responsibilities

Collaborate with a team of experts to generate robust data supporting preclinical validation of novel therapeutic targets and greater understanding of disease biology.
Independently design and execute in vitro and ex vivo mechanism-of-action experiments, including troubleshooting, assay optimization, and data collection, analysis, and interpretation.
Present research findings effectively in written and oral formats to internal teams and external collaborators.
Participate in cross-functional drug development teams as a key intellectual and technical contributor.

Benefits

Health and welfare plans for staff and eligible dependents.
Retirement and Savings Plan with generous company contributions.
Group medical, dental, and vision coverage.
Life and disability insurance.
Flexible spending accounts.
Discretionary annual bonus program, or a sales-based incentive plan for field sales representatives.
Stock-based long-term incentives.
Award-winning time-off plans.
Flexible work models where possible.
Career development opportunities.