Scientist, Biology

Alector•South San Francisco, CA

2d•$145,000 - $155,000•Hybrid

About The Position

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history. As a Scientist on our Biology team, you will design and execute in vitro studies and analytical assays that help us evaluate potential therapeutics for neurodegenerative diseases. You will work with advanced cellular models, process in vivo and in vitro samples, and generate high-quality data that inform pharmacokinetics/pharmacodynamics (PK/PD), efficacy, safety, proof-of-concept (POC), and mechanism-of-action (MOA) studies. You’ll collaborate closely with colleagues across Biology, ADPE, and Preclinical teams to advance our programs. We value scientific curiosity, thoughtful experimentation, and the ability to adapt as our science and priorities evolve.

Requirements

PhD in Neuroscience, Immunology, Biology, or a related scientific discipline.
Hands-on experience with cell culture, including iPSC-derived and/or primary rodent neuronal models.
Experience with biochemical and cellular techniques such as immunoblotting, ELISA, MSD, immunocytochemistry, flow cytometry/FACS, or immunohistochemistry.
Demonstrated ability to analyze and interpret experimental data and clearly communicate scientific findings.
You are an active user of large language models (LLMs) and have a strong interest in evolving AI technologies and how they can improve scientific research and productivity.

Nice To Haves

Experience working in a biotechnology or pharmaceutical research environment.
Experience developing or optimizing cellular models of neurodegenerative disease.
Familiarity with confocal microscopy and neurohistology techniques.

Responsibilities

Design and execute in vitro pharmacology studies using iPSC-derived cellular models, including induced neurons, induced microglia, and co-culture and triple-culture systems.
Develop and optimize cellular models of neurodegenerative disease, including Alzheimer’s disease, to enable POC and MOA studies.
Collect and process cell lysates, media, rodent brain, and other biological samples and perform downstream biochemical and cellular analyses.
Analyze, interpret, document, and communicate results while maintaining accurate experimental records, protocols, and data in our electronic lab notebook.
Collaborate across Biology, ADPE, and Preclinical teams while identifying opportunities to integrate innovative technologies, especially AI, to expedite programs, improve scientific workflows, and save valuable resources.