Scientist, Cellular Immunology Preclinical

Cabaletta Bio Inc.•Philadelphia, PA

2d•Hybrid

About The Position

We are seeking a highly skilled and motivated Scientist with expertise in cell-based assays for CAR T cell therapy. As a key member of our research and development team, you will play a crucial role in advancing the field of cellular immunotherapy by developing in vitro and ex vivo assays to contribute to enhancing the safety and efficacy of CAR T cells in preclinical settings. This position offers an exciting opportunity to contribute to groundbreaking research that has the potential to revolutionize treatment for autoimmune disease patients.

Requirements

Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field with 0-2 years, or Master's degree with a minimum of 5 years, or Bachelor’s degree with minimum of 10 years of experience.
Hands-on experience with cell culture and basic molecular biology techniques. Extensive hands-on experience with primary immune cell-based assays advantageous.
General lab skills, including aseptic techniques and human tissue handling required.
Must have prior experience and be highly skilled at mammalian cell culture (aseptic techniques).
Experience in primary cell husbandry, cytotoxicity assays, and flow cytometry.
Must be highly organized and able to work independently.
A high level of flexibility to support various other activities and the ability to learn new techniques outside of existing field of expertise.
Strong team orientation and passion for continuous self-development.
Strong organizational skills, attention to detail, and the ability to follow protocols accurately.
Effective written and verbal communication skills to share experimental findings and collaborate with team members.

Nice To Haves

Experience working in a research or industry setting related to immunology, cell therapy, or gene editing.
Experience in industry or in a startup industrial setting.
Solid understanding of CAR T cell therapy, immune cell biology, and cellular immunotherapy.
Enthusiasm for learning and contributing to innovative research in the field of CAR T cell therapy.

Responsibilities

Conduct hands-on laboratory experiments following established protocols to generate CAR T cells.
Perform and optimize cytotoxicity and flow cytometry assays.
Perform and validate ELISpot, ELISA, Luminex, or other assays as needed.
Maintain and expand, bank, and manage various cell lines.
Actively contribute to process improvements and the implementation of new technologies.
Perform lab associated tasks in accordance with Cabaletta Bio lab safety policies and SOPs.
Ensure proper maintenance and cleanliness of laboratory equipment and workspaces.
Maintain accurate and well-organized records and electronic laboratory notebook.
Analyze experimental data using basic statistical methods and software tools to generate meaningful insights.
Work collaboratively within a multidisciplinary team, actively participating in team meetings and discussions.
Communicate experimental results and findings effectively to colleagues and supervisors through written reports and oral presentations.