Scientist, CADD & Cheminformatics, based in Montreal/Quebec or remote

X-Chem•Montreal, QC

3d•Remote

About The Position

At X-Chem, it is our mission to leverage the world’s leading drug discovery platform to help create molecules that will improve human health. At X-Chem, we do more than screen compounds. We help you make confident decisions that move science forward. Our integrated platform combines DNA-encoded libraries, medicinal chemistry, advanced modeling and proprietary AI into a powerful and precise discovery engine. Everything is connected through Chemomics, our approach to unlocking value from every data point. Whether you’re exploring a new target or refining a lead, we help you discover high-quality molecules with greater speed, insight and control. X-Chem is seeking a candidate for the position of Scientist, Computer-aided Drug Design (CADD) & Cheminformatics to join our team, based in Montreal, QC, or remotely within Canada. Primary responsibilities include applying computational chemistry and cheminformatics approaches to support and guide medicinal chemistry projects, as well as developing and maintaining machine learning models. The role also offers opportunities to expand into computational method development and to engage with analytical chemistry and DMPK in the context of machine learning as part of professional development. This position provides the opportunity to be on the cutting edge of scientific development in cheminformatics and computational chemistry. This role will be reporting to Senior Director, Computational Chemistry. The ideal candidate will bring creativity, curiosity and a willingness to learn and be flexible.

Requirements

BSc and/or MSc Degree in Physical Chemistry, Computer Science or related field, and/or a PhD in the same field.
1 to 3 years of industry experience is desirable.
Proficiency in at least one programming language (e.g. Python, R, SVL)
Familiarity with computational chemistry or cheminformatics software (e.g. MOE, Schrodinger, OpenEye, RDKit)
Basic knowledge of computational chemistry principles
Bilingual (French and English).
Excellent oral and written communication skills
Good problem-solving skills.
Strong organizational skills and attention to detail with the ability to manage multiple priorities effectively.
Current work authorization in Canada

Nice To Haves

Experience with cheminformatics workflows and data processing, DNA-encoded libraries, or CDD Vault is an asset

Responsibilities

Provide computational chemistry and cheminformatics support in collaboration with medicinal chemistry teams to guide project decisions
Contribute to the development and application of machine learning approaches for drug discovery (e.g. property prediction) to support compound prioritization
Support the development and maintenance of chemistry and experimental data workflows
Support data integration and workflow development across the drug discovery pipeline and contribute to data governance