Scientist II, Cheminformatics

Relay Therapeutics • Cambridge, MA

3d • Hybrid

About The Position

Relay Therapeutics is seeking a highly motivated Scientist to join our Drug Discovery team in a unique hybrid role that integrates synthetic chemistry with cheminformatics. This position is ideal for a scientist who enjoys working at the interface of experimental and computational disciplines and is excited to help shape how data-driven chemistry is done in a modern biotech environment.

Requirements

• Ph.D. or M.S. in Organic Chemistry or a related field, with 2–5 years of relevant industry experience preferred
• Demonstrated experience in synthetic organic chemistry
• Familiarity with cheminformatics tools and concepts (e.g., molecular representations, library design, property prediction)
• Experience with scripting or data analysis tools (e.g., Python, RDKit)
• Strong problem-solving skills and the ability to work both independently and collaboratively
• Excellent communication skills and a desire to work in a highly cross-functional environment

Nice To Haves

• A scientist who enjoys bridging “hands-on” chemistry with computational thinking
• Someone comfortable working in a fast-paced, evolving biotech setting
• A candidate who is curious, adaptable, and interested in shaping new ways of integrating chemistry and data science

Responsibilities

• Maintain and support tools used in compound registration, lab operations and data ingestion from assays, as well as broader data and software access workflows
• Design and execute synthetic chemistry workflows, with a focus on high-throughput or parallel synthesis to support medicinal chemistry programs
• Contribute to the design, enumeration, and prioritization of compound libraries using cheminformatics tools
• Collaborate closely with computational chemists, data scientists, and medicinal chemists to guide compound design using data-driven insights
• Analyze and interpret experimental data to inform structure–activity relationships (SAR) and compound optimization
• Help develop and refine internal workflows that integrate synthetic chemistry with computational approaches
• Maintain clear documentation and communicate results effectively across multidisciplinary teams

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level