Scientist, Bioconjugation

Dyne Therapeutics•Waltham, MA

6d•Onsite

About The Position

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. The Scientist, Bioconjugation designs, synthesizes, purifies, characterizes, and optimizes novel bioconjugates that support Dyne’s therapeutic pipeline. This role applies expertise in bioconjugation chemistry, protein purification, oligonucleotide conjugation, and analytical characterization to solve scientific and technical challenges. Prior experience in design, synthesis, purification, and/or characterization of antibody-drug conjugates (ADCs) and/or antibody-oligonucleotide conjugates (AOCs) is a plus. The Scientist collaborates closely with colleagues across chemistry, protein engineering, analytical sciences, process development, biology, and other functions to advance therapeutic programs from discovery through development. This position is based in Waltham, MA

Requirements

PhD in chemistry, biochemistry, chemical biology, pharmaceutical sciences, or a related scientific discipline with 0–3 years of industry experience; or a master’s degree with 8+ years of relevant industry experience.
Hands-on experience in bioconjugation chemistry and protein purification.
Experience with the conjugation of proteins, peptides, antibodies, or oligonucleotides.
Strong understanding of linker chemistry, conjugation mechanisms, and site-specific modification strategies.
Hands-on experience with purification techniques, including HPLC, FPLC, size-exclusion chromatography, ion-exchange chromatography, and affinity chromatography.
Experience with analytical characterization methods such as LC-MS, UPLC, capillary electrophoresis, SDS-PAGE, UV-Vis spectroscopy, and dynamic light scattering.
Knowledge of protein chemistry, oligonucleotide therapeutics, or antibody-based therapeutics.
Ability to independently design and execute experimental work within defined research projects, applying sound scientific methodology to address increasingly complex problems.
Ability to analyze, interpret, and clearly communicate experimental data to support program advancement and scientific decision-making.
Strong scientific curiosity and an innovative, solution-oriented mindset.
Excellent experimental planning, execution, documentation, and organizational skills.
Effective written and verbal communication skills.
Strong cross-functional collaboration skills and the ability to work effectively with internal partners toward shared scientific objectives.
Ability to manage multiple priorities, meet timelines, and thrive in a fast-paced, collaborative biotechnology environment.

Nice To Haves

Prior experience in design, synthesis, purification, and/or characterization of antibody-drug conjugates (ADCs) and/or antibody-oligonucleotide conjugates (AOCs) is a plus.

Responsibilities

Designs and conducts experiments to synthesize and optimize the conjugation of oligonucleotides to proteins, peptides, and antibodies.
Develops and evaluates novel conjugation strategies, linker technologies, and site-specific modification approaches.
Purifies and characterizes bioconjugates using chromatographic, spectroscopic, and complementary analytical techniques.
Analyzes and interprets experimental data to guide molecular design, experimental strategy, and process optimization.
Independently troubleshoots complex synthetic, purification, and analytical challenges.
Collaborates with cross-functional teams to advance therapeutic candidates and achieve project milestones.
Maintains detailed and accurate experimental records and communicates findings through technical reports, presentations, and team discussions.
Contributes to internal technology development initiatives and bioconjugation platform innovation.
Supports the transfer of conjugation processes to development and manufacturing teams as programs advance.
Maintains current knowledge of emerging technologies and scientific literature in bioconjugation, protein chemistry, and oligonucleotide therapeutics.