Scientist 3 - Bioconjugation and Delivery

Roche•South San Francisco, CA

2d•$103,400 - $192,000•Onsite

About The Position

The Bioconjugation and Delivery group within Protein Sciences is at the forefront of therapeutic design, generating molecules with unique mechanisms of action. In this hands-on, laboratory-based role, you will learn and apply advanced bioconjugation techniques with precise analytical characterization to advance the next wave of antibody oligonucleotide conjugates and novel delivery strategies.

Requirements

Master’s degree or PhD in Chemistry, Biochemistry, Chemical Biology, Biophysics, Biomedical Engineering, or a related scientific discipline, combined with 3-5 years relevant research or industry experience.
Practical experience or foundational understanding of protein purification and analytical characterization techniques (such as FPLC, HPLC, or LC-MS).
Knowledge of or hands-on experience with oligonucleotides and/or antibody oligonucleotide conjugate generation.
Strong communication, collaborative mindset, and interpersonal skills to thrive in an interdisciplinary environment.

Responsibilities

Design, optimize, and execute bioconjugation of proteins using chemical and enzymatic methods.
Develop and implement purification protocols for bioconjugates using standard protein purification techniques.
Perform analytical characterization of reaction mixtures and purified conjugates using chromatographic techniques (e.g., SEC, HIC, IEX), SDS-PAGE, colorimetric assays, and mass spectrometry (1D/2D LC-MS).
Interpret experimental findings, report data clearly, and present results to cross-functional scientific teams.
Manage inventory and sample tracking for completed conjugates and starting materials using digital management systems.
Collaborate with multi-disciplinary scientific teams to advance innovative therapeutic modalities through the drug discovery pipeline.