Scientist , Antibody Discovery, In Vitro

Twist Bioscience•South San Francisco, CA

2d•$127,000 - $158,200•Onsite

About The Position

This is an individual contributor role that provides support for bioanalytical characterization for a variety of assays critical for characterizing therapeutic antibody candidates. This role will work closely with our in vitro Antibody Discovery team at our South San Francisco, CA location and is responsible for analyzing, optimizing, and troubleshooting a range of workflows, including SPR affinity analysis, and ELISA.

Requirements

Strong knowledge of antibody and biologics characterization is required.
Previous experience with Carterra SPR systems is strictly required.
Further direct experience is expected with ELISA, SDS-PAGE and protein quantification.
Ability to troubleshoot scientific processes, make sound scientific decisions on tight timelines, and accurately analyze and report data with utmost attention to detail.
Ability to work simultaneously on multiple workflows.
Effectively communicate project updates, risks, and progress to the manager and cross-functional team members in a timely and professional manner.
Actively participate in team meetings, clearly articulating needs, concerns, and proposed solutions to drive efficient collaboration.
PhD in a related technical field with 3+ years of experience in biopharmaceutical analytical development, or MS with 5+ years of relevant experience.
Extensive hands-on experience required in Carterra SPR (operation and data analysis) and ELISA workflows.
Strong track record of developing, executing, and analyzing common assay formats for antibody discovery, such as high-throughput screening, epitope binning, ligand blocking analysis, affinity analysis, and cell-based functional assays.
Demonstrated capability to work autonomously, prioritizing responsibilities within a high-pressure setting characterized by concurrent projects and time-critical workflows.
Understanding of in vitro antibody discovery concepts.
Proven ability to assess, interpret, and present complex scientific data effectively and with a high level of integrity and ethics.
Exceptional written and verbal communication skills, including external customer-facing communication.
Highly organized and detail-oriented with a focused, problem-solving mentality to address projects and logistics.

Nice To Haves

Experience in high-throughput assays (1,000s of samples) is preferred.
Flow Cytometry and antibody developability characterization experience.
Cell Based functional assays experience.

Responsibilities

Support members of multiple teams as a Project Lead, but will not directly manage team members.
Guide multiple projects per day to ensure scientific excellence and execution for antibody (IgG, VHH, Minibinders, etc.) projects involving Carterra SPR and ELISA-based workflows.
Assist cross-functionally with the wet lab teams, Project Management team and scientific leaders across multiple sites within the company to ensure exquisite execution of individual projects, while also providing guidance for future assay integration and improvement in the antibody discovery workflow.
Provide technical guidance (assay development, analysis, and data reporting) for antibody-based projects.
Serve as an SME in bioanalytical methods (SPR) for a variety of in vitro antibody discovery programs and contract services, contributing to scientific planning and feasibility review during project scoping.
Review, critically analyze, and present data to customers for a variety of concurrent antibody discovery programs.
Work closely with the Project Management team to communicate timelines and deliverables to internal and external stakeholders and customers.
Work closely with all scientific departments.
Perform wet-lab benchwork alongside the team based on workflow and assay development needs (anticipated 50/50 split of analysis vs wet lab time).
Work on other assays such as Flow Cytometry and phage/yeast display.