Scientist 1, Protein Assay Development, Spatial Biology

10x Genomics•Pleasanton, CA

6h•$123,100 - $166,500

About The Position

We are looking for an exceptional, multidisciplinary scientist to contribute to our product development efforts in our Spatial Biology department, developing technologies that map protein — and other biomolecules — directly within intact tissue. The ideal candidate will have a solid foundation in cell biology, immunology or tumor biology with strong troubleshooting skills and hands-on experience with tissue based imaging assays. This role will involve designing, running, and troubleshooting experiments to develop and optimize new assays in the area of spatial multiomics in tissues. You will collaborate closely with colleagues across chemistry, computational biology, software, engineering, and microfluidics to bring new products to life. We're looking for someone with strong analytical skills, curiosity about new technologies, and enthusiasm for working in a fast-paced, collaborative, multi-disciplinary environment.

Requirements

PhD in Cell Biology, Immunology, Biochemistry or related field.
2+ years of hands-on experience in proteomics, in situ hybridization or other imaging based spatial techniques.
Experience with tissue processing, histology, immunohistochemistry, cryosectioning, immunofluorescence including characterization by surface markers or gene expression.
Experience working with antibodies, including mAb QC, conjugation and/or functional testing.
Strong analytical background
Strong organizational skills.
Strong written and oral communication skills.
Strong troubleshooting and problem solving skills.
Ability to work in a fast-paced and quickly changing environment.
Desire to build game-changing technologies and impact the world of life science research.

Nice To Haves

Experience with multiplex protein assays is a plus
Proficiency in R, Python, AI-aided coding or specialized omics data analysis software is a plus.
Skills in image analysis are a plus.

Responsibilities

Contribute to the optimization of tissue handling and processing protocols for protein staining, including FFPE samples, to improve antigen retention, staining consistency, and compatibility with high-plex imaging workflows.
Design and execute experiments using novel imaging and biochemistry platforms integral to various spatial technology platforms under development at 10x Genomics. This includes in-depth analysis and reporting of your data through documentation and presentations to internal groups.
Work closely with computational biologists and software engineers to interpret data generated by novel optical and biochemical assays.